Vitamin E plus aspirin compared with aspirin alone in patients with transient ischemic attacks

Manfred Steiner, Michael Glantz, Andrew Lekos

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

One hundred patients with transient ischemic attacks, minor strokes, or residual ischemic neurologic deficits were enrolled in a double-blind, randomized study comparing the effects of aspirin plus vitamin E [0.4 g (400 IU)/d; n = 52] with aspirin alone (325 mg; n = 48). The patients received study medication for 2 y or until they reached a termination point. Preliminary results show a significant reduction in the incidence of ischemic events in patients in the vitamin E plus aspirin group compared with patients taking only aspirin. There was no significant difference in the incidence of hemorrhagic stroke although both patients who developed it were taking vitamin E. Platelet adhesion was also measured in a randomized subgroup of both study populations by using collagen III as the adhesive surface. There was a highly significant reduction in platelet adhesiveness in patients who were taking vitamin E plus aspirin compared with those taking aspirin only. Measurement of α-tocopherol concentrations confirmed compliance of the patients with the medication schedule, showing a near doubling of serum concentrations of α-tocopherol. We concluded that the combination of vitamin E and a platelet antiaggregating agent (eg, aspirin) significantly enhances the efficacy of the preventive treatment regimen in patients with transient ischemic attacks and other ischemic cerebrovascular problems.

Original languageEnglish (US)
Pages (from-to)1381S-1384S
JournalAmerican Journal of Clinical Nutrition
Volume62
Issue number6 SUPPL.
DOIs
StatePublished - Dec 1995

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Transient Ischemic Attack
Vitamin E
Aspirin
Tocopherols
Blood Platelets
Stroke
Platelet Adhesiveness
Incidence
Patient Compliance
Neurologic Manifestations
Double-Blind Method
Adhesives
Appointments and Schedules
Collagen
Serum
Population

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

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abstract = "One hundred patients with transient ischemic attacks, minor strokes, or residual ischemic neurologic deficits were enrolled in a double-blind, randomized study comparing the effects of aspirin plus vitamin E [0.4 g (400 IU)/d; n = 52] with aspirin alone (325 mg; n = 48). The patients received study medication for 2 y or until they reached a termination point. Preliminary results show a significant reduction in the incidence of ischemic events in patients in the vitamin E plus aspirin group compared with patients taking only aspirin. There was no significant difference in the incidence of hemorrhagic stroke although both patients who developed it were taking vitamin E. Platelet adhesion was also measured in a randomized subgroup of both study populations by using collagen III as the adhesive surface. There was a highly significant reduction in platelet adhesiveness in patients who were taking vitamin E plus aspirin compared with those taking aspirin only. Measurement of α-tocopherol concentrations confirmed compliance of the patients with the medication schedule, showing a near doubling of serum concentrations of α-tocopherol. We concluded that the combination of vitamin E and a platelet antiaggregating agent (eg, aspirin) significantly enhances the efficacy of the preventive treatment regimen in patients with transient ischemic attacks and other ischemic cerebrovascular problems.",
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Vitamin E plus aspirin compared with aspirin alone in patients with transient ischemic attacks. / Steiner, Manfred; Glantz, Michael; Lekos, Andrew.

In: American Journal of Clinical Nutrition, Vol. 62, No. 6 SUPPL., 12.1995, p. 1381S-1384S.

Research output: Contribution to journalArticle

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