Vitamin or mineral supplement intake and the risk of head and neck cancer

Pooled analysis in the INHANCE consortium

Qian Li, Shu Chun Chuang, Jose Eluf-Neto, Ana Menezes, Elena Matos, Sergio Koifman, Victor Wünsch-Filho, Leticia Fernandez, Alexander W. Daudt, Maria Paula Curado, Deborah M. Winn, Silvia Franceschi, Rolando Herrero, Xavier Castellsague, Hal Morgenstern, Zuo Feng Zhang, Philip Lazarus, Joshua Muscat, Michael McClean, Karl T. Kelsey & 12 others Richard B. Hayes, Mark P. Purdue, Stephen M. Schwartz, Chu Chen, Simone Benhamou, Andrew F. Olshan, Guopei Yu, Stimson Schantz, Gilles Ferro, Paul Brennan, Paolo Boffetta, Mia Hashibe

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To investigate the potential role of vitamin or mineral supplementation on the risk of head and neck cancer (HNC), we analyzed individual-level pooled data from 12 case-control studies (7,002 HNC cases and 8,383 controls) participating in the International Head and Neck Cancer Epidemiology consortium. There were a total of 2,028 oral cavity cancer, 2,465 pharyngeal cancer, 874 unspecified oral/pharynx cancer, 1,329 laryngeal cancer and 306 overlapping HNC cases. Odds ratios (OR) and 95% confidence intervals (CIs) for self reported ever use of any vitamins, multivitamins, vitamin A, vitamin C, vitamin E, and calcium, beta-carotene, iron, selenium and zinc supplements were assessed. We further examined frequency, duration and cumulative exposure of each vitamin or mineral when possible and stratified by smoking and drinking status. All ORs were adjusted for age, sex, race/ethnicity, study center, education level, pack-years of smoking, frequency of alcohol drinking and fruit/vegetable intake. A decreased risk of HNC was observed with ever use of vitamin C (OR = 0.76, 95% CI = 0.59-0.96) and with ever use of calcium supplement (OR = 0.64, 95% CI = 0.42-0.97). The inverse association with HNC risk was also observed for 10 or more years of vitamin C use (OR = 0.72, 95% CI = 0.54-0.97) and more than 365 tablets of cumulative calcium intake (OR = 0.36, 95% CI = 0.16-0.83), but linear trends were not observed for the frequency or duration of any supplement intake. We did not observe any strong associations between vitamin or mineral supplement intake and the risk of HNC.

Original languageEnglish (US)
Pages (from-to)1686-1699
Number of pages14
JournalInternational Journal of Cancer
Volume131
Issue number7
DOIs
StatePublished - Oct 1 2012

Fingerprint

Head and Neck Neoplasms
Vitamins
Minerals
Odds Ratio
Confidence Intervals
Ascorbic Acid
Mouth Neoplasms
Calcium
Smoking
Pharyngeal Neoplasms
Laryngeal Neoplasms
beta Carotene
Selenium
Pharynx
Vitamin A
Vitamin E
Alcohol Drinking
Vegetables
Tablets
Drinking

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Li, Q., Chuang, S. C., Eluf-Neto, J., Menezes, A., Matos, E., Koifman, S., ... Hashibe, M. (2012). Vitamin or mineral supplement intake and the risk of head and neck cancer: Pooled analysis in the INHANCE consortium. International Journal of Cancer, 131(7), 1686-1699. https://doi.org/10.1002/ijc.27405
Li, Qian ; Chuang, Shu Chun ; Eluf-Neto, Jose ; Menezes, Ana ; Matos, Elena ; Koifman, Sergio ; Wünsch-Filho, Victor ; Fernandez, Leticia ; Daudt, Alexander W. ; Curado, Maria Paula ; Winn, Deborah M. ; Franceschi, Silvia ; Herrero, Rolando ; Castellsague, Xavier ; Morgenstern, Hal ; Zhang, Zuo Feng ; Lazarus, Philip ; Muscat, Joshua ; McClean, Michael ; Kelsey, Karl T. ; Hayes, Richard B. ; Purdue, Mark P. ; Schwartz, Stephen M. ; Chen, Chu ; Benhamou, Simone ; Olshan, Andrew F. ; Yu, Guopei ; Schantz, Stimson ; Ferro, Gilles ; Brennan, Paul ; Boffetta, Paolo ; Hashibe, Mia. / Vitamin or mineral supplement intake and the risk of head and neck cancer : Pooled analysis in the INHANCE consortium. In: International Journal of Cancer. 2012 ; Vol. 131, No. 7. pp. 1686-1699.
@article{6dc24664bce24f4181fbe32409515a26,
title = "Vitamin or mineral supplement intake and the risk of head and neck cancer: Pooled analysis in the INHANCE consortium",
abstract = "To investigate the potential role of vitamin or mineral supplementation on the risk of head and neck cancer (HNC), we analyzed individual-level pooled data from 12 case-control studies (7,002 HNC cases and 8,383 controls) participating in the International Head and Neck Cancer Epidemiology consortium. There were a total of 2,028 oral cavity cancer, 2,465 pharyngeal cancer, 874 unspecified oral/pharynx cancer, 1,329 laryngeal cancer and 306 overlapping HNC cases. Odds ratios (OR) and 95{\%} confidence intervals (CIs) for self reported ever use of any vitamins, multivitamins, vitamin A, vitamin C, vitamin E, and calcium, beta-carotene, iron, selenium and zinc supplements were assessed. We further examined frequency, duration and cumulative exposure of each vitamin or mineral when possible and stratified by smoking and drinking status. All ORs were adjusted for age, sex, race/ethnicity, study center, education level, pack-years of smoking, frequency of alcohol drinking and fruit/vegetable intake. A decreased risk of HNC was observed with ever use of vitamin C (OR = 0.76, 95{\%} CI = 0.59-0.96) and with ever use of calcium supplement (OR = 0.64, 95{\%} CI = 0.42-0.97). The inverse association with HNC risk was also observed for 10 or more years of vitamin C use (OR = 0.72, 95{\%} CI = 0.54-0.97) and more than 365 tablets of cumulative calcium intake (OR = 0.36, 95{\%} CI = 0.16-0.83), but linear trends were not observed for the frequency or duration of any supplement intake. We did not observe any strong associations between vitamin or mineral supplement intake and the risk of HNC.",
author = "Qian Li and Chuang, {Shu Chun} and Jose Eluf-Neto and Ana Menezes and Elena Matos and Sergio Koifman and Victor W{\"u}nsch-Filho and Leticia Fernandez and Daudt, {Alexander W.} and Curado, {Maria Paula} and Winn, {Deborah M.} and Silvia Franceschi and Rolando Herrero and Xavier Castellsague and Hal Morgenstern and Zhang, {Zuo Feng} and Philip Lazarus and Joshua Muscat and Michael McClean and Kelsey, {Karl T.} and Hayes, {Richard B.} and Purdue, {Mark P.} and Schwartz, {Stephen M.} and Chu Chen and Simone Benhamou and Olshan, {Andrew F.} and Guopei Yu and Stimson Schantz and Gilles Ferro and Paul Brennan and Paolo Boffetta and Mia Hashibe",
year = "2012",
month = "10",
day = "1",
doi = "10.1002/ijc.27405",
language = "English (US)",
volume = "131",
pages = "1686--1699",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "7",

}

Li, Q, Chuang, SC, Eluf-Neto, J, Menezes, A, Matos, E, Koifman, S, Wünsch-Filho, V, Fernandez, L, Daudt, AW, Curado, MP, Winn, DM, Franceschi, S, Herrero, R, Castellsague, X, Morgenstern, H, Zhang, ZF, Lazarus, P, Muscat, J, McClean, M, Kelsey, KT, Hayes, RB, Purdue, MP, Schwartz, SM, Chen, C, Benhamou, S, Olshan, AF, Yu, G, Schantz, S, Ferro, G, Brennan, P, Boffetta, P & Hashibe, M 2012, 'Vitamin or mineral supplement intake and the risk of head and neck cancer: Pooled analysis in the INHANCE consortium', International Journal of Cancer, vol. 131, no. 7, pp. 1686-1699. https://doi.org/10.1002/ijc.27405

Vitamin or mineral supplement intake and the risk of head and neck cancer : Pooled analysis in the INHANCE consortium. / Li, Qian; Chuang, Shu Chun; Eluf-Neto, Jose; Menezes, Ana; Matos, Elena; Koifman, Sergio; Wünsch-Filho, Victor; Fernandez, Leticia; Daudt, Alexander W.; Curado, Maria Paula; Winn, Deborah M.; Franceschi, Silvia; Herrero, Rolando; Castellsague, Xavier; Morgenstern, Hal; Zhang, Zuo Feng; Lazarus, Philip; Muscat, Joshua; McClean, Michael; Kelsey, Karl T.; Hayes, Richard B.; Purdue, Mark P.; Schwartz, Stephen M.; Chen, Chu; Benhamou, Simone; Olshan, Andrew F.; Yu, Guopei; Schantz, Stimson; Ferro, Gilles; Brennan, Paul; Boffetta, Paolo; Hashibe, Mia.

In: International Journal of Cancer, Vol. 131, No. 7, 01.10.2012, p. 1686-1699.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Vitamin or mineral supplement intake and the risk of head and neck cancer

T2 - Pooled analysis in the INHANCE consortium

AU - Li, Qian

AU - Chuang, Shu Chun

AU - Eluf-Neto, Jose

AU - Menezes, Ana

AU - Matos, Elena

AU - Koifman, Sergio

AU - Wünsch-Filho, Victor

AU - Fernandez, Leticia

AU - Daudt, Alexander W.

AU - Curado, Maria Paula

AU - Winn, Deborah M.

AU - Franceschi, Silvia

AU - Herrero, Rolando

AU - Castellsague, Xavier

AU - Morgenstern, Hal

AU - Zhang, Zuo Feng

AU - Lazarus, Philip

AU - Muscat, Joshua

AU - McClean, Michael

AU - Kelsey, Karl T.

AU - Hayes, Richard B.

AU - Purdue, Mark P.

AU - Schwartz, Stephen M.

AU - Chen, Chu

AU - Benhamou, Simone

AU - Olshan, Andrew F.

AU - Yu, Guopei

AU - Schantz, Stimson

AU - Ferro, Gilles

AU - Brennan, Paul

AU - Boffetta, Paolo

AU - Hashibe, Mia

PY - 2012/10/1

Y1 - 2012/10/1

N2 - To investigate the potential role of vitamin or mineral supplementation on the risk of head and neck cancer (HNC), we analyzed individual-level pooled data from 12 case-control studies (7,002 HNC cases and 8,383 controls) participating in the International Head and Neck Cancer Epidemiology consortium. There were a total of 2,028 oral cavity cancer, 2,465 pharyngeal cancer, 874 unspecified oral/pharynx cancer, 1,329 laryngeal cancer and 306 overlapping HNC cases. Odds ratios (OR) and 95% confidence intervals (CIs) for self reported ever use of any vitamins, multivitamins, vitamin A, vitamin C, vitamin E, and calcium, beta-carotene, iron, selenium and zinc supplements were assessed. We further examined frequency, duration and cumulative exposure of each vitamin or mineral when possible and stratified by smoking and drinking status. All ORs were adjusted for age, sex, race/ethnicity, study center, education level, pack-years of smoking, frequency of alcohol drinking and fruit/vegetable intake. A decreased risk of HNC was observed with ever use of vitamin C (OR = 0.76, 95% CI = 0.59-0.96) and with ever use of calcium supplement (OR = 0.64, 95% CI = 0.42-0.97). The inverse association with HNC risk was also observed for 10 or more years of vitamin C use (OR = 0.72, 95% CI = 0.54-0.97) and more than 365 tablets of cumulative calcium intake (OR = 0.36, 95% CI = 0.16-0.83), but linear trends were not observed for the frequency or duration of any supplement intake. We did not observe any strong associations between vitamin or mineral supplement intake and the risk of HNC.

AB - To investigate the potential role of vitamin or mineral supplementation on the risk of head and neck cancer (HNC), we analyzed individual-level pooled data from 12 case-control studies (7,002 HNC cases and 8,383 controls) participating in the International Head and Neck Cancer Epidemiology consortium. There were a total of 2,028 oral cavity cancer, 2,465 pharyngeal cancer, 874 unspecified oral/pharynx cancer, 1,329 laryngeal cancer and 306 overlapping HNC cases. Odds ratios (OR) and 95% confidence intervals (CIs) for self reported ever use of any vitamins, multivitamins, vitamin A, vitamin C, vitamin E, and calcium, beta-carotene, iron, selenium and zinc supplements were assessed. We further examined frequency, duration and cumulative exposure of each vitamin or mineral when possible and stratified by smoking and drinking status. All ORs were adjusted for age, sex, race/ethnicity, study center, education level, pack-years of smoking, frequency of alcohol drinking and fruit/vegetable intake. A decreased risk of HNC was observed with ever use of vitamin C (OR = 0.76, 95% CI = 0.59-0.96) and with ever use of calcium supplement (OR = 0.64, 95% CI = 0.42-0.97). The inverse association with HNC risk was also observed for 10 or more years of vitamin C use (OR = 0.72, 95% CI = 0.54-0.97) and more than 365 tablets of cumulative calcium intake (OR = 0.36, 95% CI = 0.16-0.83), but linear trends were not observed for the frequency or duration of any supplement intake. We did not observe any strong associations between vitamin or mineral supplement intake and the risk of HNC.

UR - http://www.scopus.com/inward/record.url?scp=84864454551&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864454551&partnerID=8YFLogxK

U2 - 10.1002/ijc.27405

DO - 10.1002/ijc.27405

M3 - Article

VL - 131

SP - 1686

EP - 1699

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 7

ER -