VLSI-based system for localization of extracellular potentials

Seth Wolpert, Michael J. Osborn, A. Marie O'Neill

Research output: Contribution to journalArticle

Abstract

In this study, an interface between a biological nerve fiber and an arbitrary electromechanical device was implemented using an analog VLSI-based amplifier/filter circuit. A silastic cuff was fitted over a live nerve bundle, and an electrode of Teflon coated silver wire was used to sense extracellular potentials. A dedicated CMOS VLSI-based circuit then filtered and amplified those signals to an amplitude appropriate for triggering an arbitrary circuit such as the four-phase stepper motor used in this study. In circuit tests, the amplifier/filter circuit was capable of sensing signals as low as 50 microvolts in an in vitro preparation of the optic nerve of limulus polyphemus, and effect rotation of the four-phase stepper motor with detected impulses. Using a silastic cuff electrode and dedicated VLSI circuitry for compactness and reliability, this circuit has excellent long term potential as a component of a surgically implanted system. It is also a pivotal first step in the implementation of a comprehensive cybernetic interface.

Original languageEnglish (US)
Pages (from-to)972-973
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume16
Issue numberpt 2
StatePublished - 1994

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Electrodes
Cybernetics
Horseshoe Crabs
Networks (circuits)
Polytetrafluoroethylene
Optic Nerve
Nerve Fibers
Silver
Equipment and Supplies
Electromechanical devices
Polytetrafluoroethylenes
baysilon
Optics
Wire
Fibers
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Bioengineering

Cite this

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VLSI-based system for localization of extracellular potentials. / Wolpert, Seth; Osborn, Michael J.; O'Neill, A. Marie.

In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Vol. 16, No. pt 2, 1994, p. 972-973.

Research output: Contribution to journalArticle

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