VO2 kinetics and clinical factors among patients with peripheral artery disease

Raphael Mendes Ritti-Dias, Ji Li, Kimberly M. Hollabaugh, Julie A. Stoner, Polly S. Montgomery, Andrew W. Gardner

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

PURPOSE: To investigate the association between oxygen uptake ( VO 2 ) kinetics and demographic, behavioral, and clinical factors among patients with peripheral artery disease (PAD). METHODS: A total of 85 PAD patients with intermittent claudication performed a constant load treadmill test, and breath-by-breath VO2 was obtained to assess VO2 kinetics. Demographic information, anthropometry, cardiovascular risk factors, and comorbid conditions were recorded. RESULTS: Using univariate analyses, higher values of tau ([τ], ie, slowed VO2 kinetics) were associated with female gender, non-Caucasian race, hypertension, dyslipidemia, and age ≤ 66 years. Smoking, diabetes, obesity, metabolic syndrome, height, and ankle brachial index were not significantly related to VO2 kinetics. Using multiple regression procedures, the identified predictors of slowed VO2 kinetics were female gender (4.76 [95% CI: 1.49-8.03] seconds; P = .0049), non- Caucasian race (4.70 [95% CI: 1.29-8.12] seconds; P = .0075), hypertension (12.06 [95% CI: 8.83-15.28] seconds; P < .0001), and age ≤ 66 years (4.97 [95% CI: 1.95-7.99] seconds; P = .0015). CONCLUSIONS: In PAD patients, slowed VO2 kinetics are associated with demographic and clinical factors. The clinical significance is that female, non-Caucasian, and hypertensive PAD patients present central and/or peripheral limitations that may partially account for their walking impairment.

Original languageEnglish (US)
Pages (from-to)411-418
Number of pages8
JournalJournal of Cardiopulmonary Rehabilitation and Prevention
Volume33
Issue number6
DOIs
StatePublished - Nov 1 2013

Fingerprint

Peripheral Arterial Disease
Demography
Hypertension
Ankle Brachial Index
Intermittent Claudication
Anthropometry
Dyslipidemias
Exercise Test
Walking
Obesity
Smoking
Oxygen

All Science Journal Classification (ASJC) codes

  • Rehabilitation
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Ritti-Dias, Raphael Mendes ; Li, Ji ; Hollabaugh, Kimberly M. ; Stoner, Julie A. ; Montgomery, Polly S. ; Gardner, Andrew W. / VO2 kinetics and clinical factors among patients with peripheral artery disease. In: Journal of Cardiopulmonary Rehabilitation and Prevention. 2013 ; Vol. 33, No. 6. pp. 411-418.
@article{8475dcae84614d0888bf11602e8168bb,
title = "VO2 kinetics and clinical factors among patients with peripheral artery disease",
abstract = "PURPOSE: To investigate the association between oxygen uptake ( VO 2 ) kinetics and demographic, behavioral, and clinical factors among patients with peripheral artery disease (PAD). METHODS: A total of 85 PAD patients with intermittent claudication performed a constant load treadmill test, and breath-by-breath VO2 was obtained to assess VO2 kinetics. Demographic information, anthropometry, cardiovascular risk factors, and comorbid conditions were recorded. RESULTS: Using univariate analyses, higher values of tau ([τ], ie, slowed VO2 kinetics) were associated with female gender, non-Caucasian race, hypertension, dyslipidemia, and age ≤ 66 years. Smoking, diabetes, obesity, metabolic syndrome, height, and ankle brachial index were not significantly related to VO2 kinetics. Using multiple regression procedures, the identified predictors of slowed VO2 kinetics were female gender (4.76 [95{\%} CI: 1.49-8.03] seconds; P = .0049), non- Caucasian race (4.70 [95{\%} CI: 1.29-8.12] seconds; P = .0075), hypertension (12.06 [95{\%} CI: 8.83-15.28] seconds; P < .0001), and age ≤ 66 years (4.97 [95{\%} CI: 1.95-7.99] seconds; P = .0015). CONCLUSIONS: In PAD patients, slowed VO2 kinetics are associated with demographic and clinical factors. The clinical significance is that female, non-Caucasian, and hypertensive PAD patients present central and/or peripheral limitations that may partially account for their walking impairment.",
author = "Ritti-Dias, {Raphael Mendes} and Ji Li and Hollabaugh, {Kimberly M.} and Stoner, {Julie A.} and Montgomery, {Polly S.} and Gardner, {Andrew W.}",
year = "2013",
month = "11",
day = "1",
doi = "10.1097/HCR.0000000000000025",
language = "English (US)",
volume = "33",
pages = "411--418",
journal = "Journal of Cardiopulmonary Rehabilitation and Prevention",
issn = "1932-7501",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

VO2 kinetics and clinical factors among patients with peripheral artery disease. / Ritti-Dias, Raphael Mendes; Li, Ji; Hollabaugh, Kimberly M.; Stoner, Julie A.; Montgomery, Polly S.; Gardner, Andrew W.

In: Journal of Cardiopulmonary Rehabilitation and Prevention, Vol. 33, No. 6, 01.11.2013, p. 411-418.

Research output: Contribution to journalArticle

TY - JOUR

T1 - VO2 kinetics and clinical factors among patients with peripheral artery disease

AU - Ritti-Dias, Raphael Mendes

AU - Li, Ji

AU - Hollabaugh, Kimberly M.

AU - Stoner, Julie A.

AU - Montgomery, Polly S.

AU - Gardner, Andrew W.

PY - 2013/11/1

Y1 - 2013/11/1

N2 - PURPOSE: To investigate the association between oxygen uptake ( VO 2 ) kinetics and demographic, behavioral, and clinical factors among patients with peripheral artery disease (PAD). METHODS: A total of 85 PAD patients with intermittent claudication performed a constant load treadmill test, and breath-by-breath VO2 was obtained to assess VO2 kinetics. Demographic information, anthropometry, cardiovascular risk factors, and comorbid conditions were recorded. RESULTS: Using univariate analyses, higher values of tau ([τ], ie, slowed VO2 kinetics) were associated with female gender, non-Caucasian race, hypertension, dyslipidemia, and age ≤ 66 years. Smoking, diabetes, obesity, metabolic syndrome, height, and ankle brachial index were not significantly related to VO2 kinetics. Using multiple regression procedures, the identified predictors of slowed VO2 kinetics were female gender (4.76 [95% CI: 1.49-8.03] seconds; P = .0049), non- Caucasian race (4.70 [95% CI: 1.29-8.12] seconds; P = .0075), hypertension (12.06 [95% CI: 8.83-15.28] seconds; P < .0001), and age ≤ 66 years (4.97 [95% CI: 1.95-7.99] seconds; P = .0015). CONCLUSIONS: In PAD patients, slowed VO2 kinetics are associated with demographic and clinical factors. The clinical significance is that female, non-Caucasian, and hypertensive PAD patients present central and/or peripheral limitations that may partially account for their walking impairment.

AB - PURPOSE: To investigate the association between oxygen uptake ( VO 2 ) kinetics and demographic, behavioral, and clinical factors among patients with peripheral artery disease (PAD). METHODS: A total of 85 PAD patients with intermittent claudication performed a constant load treadmill test, and breath-by-breath VO2 was obtained to assess VO2 kinetics. Demographic information, anthropometry, cardiovascular risk factors, and comorbid conditions were recorded. RESULTS: Using univariate analyses, higher values of tau ([τ], ie, slowed VO2 kinetics) were associated with female gender, non-Caucasian race, hypertension, dyslipidemia, and age ≤ 66 years. Smoking, diabetes, obesity, metabolic syndrome, height, and ankle brachial index were not significantly related to VO2 kinetics. Using multiple regression procedures, the identified predictors of slowed VO2 kinetics were female gender (4.76 [95% CI: 1.49-8.03] seconds; P = .0049), non- Caucasian race (4.70 [95% CI: 1.29-8.12] seconds; P = .0075), hypertension (12.06 [95% CI: 8.83-15.28] seconds; P < .0001), and age ≤ 66 years (4.97 [95% CI: 1.95-7.99] seconds; P = .0015). CONCLUSIONS: In PAD patients, slowed VO2 kinetics are associated with demographic and clinical factors. The clinical significance is that female, non-Caucasian, and hypertensive PAD patients present central and/or peripheral limitations that may partially account for their walking impairment.

UR - http://www.scopus.com/inward/record.url?scp=84890038844&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890038844&partnerID=8YFLogxK

U2 - 10.1097/HCR.0000000000000025

DO - 10.1097/HCR.0000000000000025

M3 - Article

C2 - 24189215

AN - SCOPUS:84890038844

VL - 33

SP - 411

EP - 418

JO - Journal of Cardiopulmonary Rehabilitation and Prevention

JF - Journal of Cardiopulmonary Rehabilitation and Prevention

SN - 1932-7501

IS - 6

ER -