Voxel-based morphometric multisite collaborative study on schizophrenia

Judith M. Segall, Jessica A. Turner, Theo G.M. Van Erp, Tonya White, H. Jeremy Bockholt, Randy L. Gollub, Beng C. Ho, Vince Magnotta, Rex E. Jung, Robert W. McCarley, S. Charles Schulz, John Lauriello, Vince P. Clark, James T. Voyvodic, Michele T. Diaz, Vince D. Calhoun

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Regional gray matter (GM) abnormalities are well known to exist in patients with chronic schizophrenia. Voxel-based morphometry (VBM) has been previously used on structural magnetic resonance images (MRI) data to characterize these abnormalities. Two multisite schizophrenia studies, the Functional Biomedical Informatics Research Network and the Mind Clinical Imaging Consortium, which include 9 data collection sites, are evaluating the efficacy of pooling structural imaging data across imaging centers. Such a pooling of data could yield the increased statistical power needed to elucidate effects that may not be seen with smaller samples. VBM analyses were performed to evaluate the consistency of patient versus control gray matter concentration (GMC) differences across the study sites, as well as the effects of combining multisite data. Integration of data from both studies yielded a large sample of 503 subjects, including 266 controls and 237 patients diagnosed with schizophrenia, schizoaffective or schizophreniform disorder. The data were analyzed using the combined sample, as well as analyzing each of the 2 multisite studies separately. A consistent pattern of reduced relative GMC in schizophrenia patients compared with controls was found across all study sites. Imaging center-specific effects were evaluated using a region of interest analysis. Overall, the findings support the use of VBM in combined multisite studies. This analysis of schizophrenics and controls from around the United States provides continued supporting evidence for GM deficits in the temporal lobes, anterior cingulate, and frontal regions in patients with schizophrenia spectrum disorders.

Original languageEnglish (US)
Pages (from-to)82-95
Number of pages14
JournalSchizophrenia Bulletin
Volume35
Issue number1
DOIs
StatePublished - Jan 1 2009

Fingerprint

Schizophrenia
Gyrus Cinguli
Psychotic Disorders
Informatics
Temporal Lobe
Meta-Analysis
Biomedical Research
Magnetic Resonance Spectroscopy
Gray Matter

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Cite this

Segall, J. M., Turner, J. A., Van Erp, T. G. M., White, T., Bockholt, H. J., Gollub, R. L., ... Calhoun, V. D. (2009). Voxel-based morphometric multisite collaborative study on schizophrenia. Schizophrenia Bulletin, 35(1), 82-95. https://doi.org/10.1093/schbul/sbn150
Segall, Judith M. ; Turner, Jessica A. ; Van Erp, Theo G.M. ; White, Tonya ; Bockholt, H. Jeremy ; Gollub, Randy L. ; Ho, Beng C. ; Magnotta, Vince ; Jung, Rex E. ; McCarley, Robert W. ; Schulz, S. Charles ; Lauriello, John ; Clark, Vince P. ; Voyvodic, James T. ; Diaz, Michele T. ; Calhoun, Vince D. / Voxel-based morphometric multisite collaborative study on schizophrenia. In: Schizophrenia Bulletin. 2009 ; Vol. 35, No. 1. pp. 82-95.
@article{9f416cd4a8354a9aaa80ccaf59508939,
title = "Voxel-based morphometric multisite collaborative study on schizophrenia",
abstract = "Regional gray matter (GM) abnormalities are well known to exist in patients with chronic schizophrenia. Voxel-based morphometry (VBM) has been previously used on structural magnetic resonance images (MRI) data to characterize these abnormalities. Two multisite schizophrenia studies, the Functional Biomedical Informatics Research Network and the Mind Clinical Imaging Consortium, which include 9 data collection sites, are evaluating the efficacy of pooling structural imaging data across imaging centers. Such a pooling of data could yield the increased statistical power needed to elucidate effects that may not be seen with smaller samples. VBM analyses were performed to evaluate the consistency of patient versus control gray matter concentration (GMC) differences across the study sites, as well as the effects of combining multisite data. Integration of data from both studies yielded a large sample of 503 subjects, including 266 controls and 237 patients diagnosed with schizophrenia, schizoaffective or schizophreniform disorder. The data were analyzed using the combined sample, as well as analyzing each of the 2 multisite studies separately. A consistent pattern of reduced relative GMC in schizophrenia patients compared with controls was found across all study sites. Imaging center-specific effects were evaluated using a region of interest analysis. Overall, the findings support the use of VBM in combined multisite studies. This analysis of schizophrenics and controls from around the United States provides continued supporting evidence for GM deficits in the temporal lobes, anterior cingulate, and frontal regions in patients with schizophrenia spectrum disorders.",
author = "Segall, {Judith M.} and Turner, {Jessica A.} and {Van Erp}, {Theo G.M.} and Tonya White and Bockholt, {H. Jeremy} and Gollub, {Randy L.} and Ho, {Beng C.} and Vince Magnotta and Jung, {Rex E.} and McCarley, {Robert W.} and Schulz, {S. Charles} and John Lauriello and Clark, {Vince P.} and Voyvodic, {James T.} and Diaz, {Michele T.} and Calhoun, {Vince D.}",
year = "2009",
month = "1",
day = "1",
doi = "10.1093/schbul/sbn150",
language = "English (US)",
volume = "35",
pages = "82--95",
journal = "Schizophrenia Bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",
number = "1",

}

Segall, JM, Turner, JA, Van Erp, TGM, White, T, Bockholt, HJ, Gollub, RL, Ho, BC, Magnotta, V, Jung, RE, McCarley, RW, Schulz, SC, Lauriello, J, Clark, VP, Voyvodic, JT, Diaz, MT & Calhoun, VD 2009, 'Voxel-based morphometric multisite collaborative study on schizophrenia', Schizophrenia Bulletin, vol. 35, no. 1, pp. 82-95. https://doi.org/10.1093/schbul/sbn150

Voxel-based morphometric multisite collaborative study on schizophrenia. / Segall, Judith M.; Turner, Jessica A.; Van Erp, Theo G.M.; White, Tonya; Bockholt, H. Jeremy; Gollub, Randy L.; Ho, Beng C.; Magnotta, Vince; Jung, Rex E.; McCarley, Robert W.; Schulz, S. Charles; Lauriello, John; Clark, Vince P.; Voyvodic, James T.; Diaz, Michele T.; Calhoun, Vince D.

In: Schizophrenia Bulletin, Vol. 35, No. 1, 01.01.2009, p. 82-95.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Voxel-based morphometric multisite collaborative study on schizophrenia

AU - Segall, Judith M.

AU - Turner, Jessica A.

AU - Van Erp, Theo G.M.

AU - White, Tonya

AU - Bockholt, H. Jeremy

AU - Gollub, Randy L.

AU - Ho, Beng C.

AU - Magnotta, Vince

AU - Jung, Rex E.

AU - McCarley, Robert W.

AU - Schulz, S. Charles

AU - Lauriello, John

AU - Clark, Vince P.

AU - Voyvodic, James T.

AU - Diaz, Michele T.

AU - Calhoun, Vince D.

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Regional gray matter (GM) abnormalities are well known to exist in patients with chronic schizophrenia. Voxel-based morphometry (VBM) has been previously used on structural magnetic resonance images (MRI) data to characterize these abnormalities. Two multisite schizophrenia studies, the Functional Biomedical Informatics Research Network and the Mind Clinical Imaging Consortium, which include 9 data collection sites, are evaluating the efficacy of pooling structural imaging data across imaging centers. Such a pooling of data could yield the increased statistical power needed to elucidate effects that may not be seen with smaller samples. VBM analyses were performed to evaluate the consistency of patient versus control gray matter concentration (GMC) differences across the study sites, as well as the effects of combining multisite data. Integration of data from both studies yielded a large sample of 503 subjects, including 266 controls and 237 patients diagnosed with schizophrenia, schizoaffective or schizophreniform disorder. The data were analyzed using the combined sample, as well as analyzing each of the 2 multisite studies separately. A consistent pattern of reduced relative GMC in schizophrenia patients compared with controls was found across all study sites. Imaging center-specific effects were evaluated using a region of interest analysis. Overall, the findings support the use of VBM in combined multisite studies. This analysis of schizophrenics and controls from around the United States provides continued supporting evidence for GM deficits in the temporal lobes, anterior cingulate, and frontal regions in patients with schizophrenia spectrum disorders.

AB - Regional gray matter (GM) abnormalities are well known to exist in patients with chronic schizophrenia. Voxel-based morphometry (VBM) has been previously used on structural magnetic resonance images (MRI) data to characterize these abnormalities. Two multisite schizophrenia studies, the Functional Biomedical Informatics Research Network and the Mind Clinical Imaging Consortium, which include 9 data collection sites, are evaluating the efficacy of pooling structural imaging data across imaging centers. Such a pooling of data could yield the increased statistical power needed to elucidate effects that may not be seen with smaller samples. VBM analyses were performed to evaluate the consistency of patient versus control gray matter concentration (GMC) differences across the study sites, as well as the effects of combining multisite data. Integration of data from both studies yielded a large sample of 503 subjects, including 266 controls and 237 patients diagnosed with schizophrenia, schizoaffective or schizophreniform disorder. The data were analyzed using the combined sample, as well as analyzing each of the 2 multisite studies separately. A consistent pattern of reduced relative GMC in schizophrenia patients compared with controls was found across all study sites. Imaging center-specific effects were evaluated using a region of interest analysis. Overall, the findings support the use of VBM in combined multisite studies. This analysis of schizophrenics and controls from around the United States provides continued supporting evidence for GM deficits in the temporal lobes, anterior cingulate, and frontal regions in patients with schizophrenia spectrum disorders.

UR - http://www.scopus.com/inward/record.url?scp=57749202506&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57749202506&partnerID=8YFLogxK

U2 - 10.1093/schbul/sbn150

DO - 10.1093/schbul/sbn150

M3 - Article

C2 - 18997157

AN - SCOPUS:57749202506

VL - 35

SP - 82

EP - 95

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

IS - 1

ER -

Segall JM, Turner JA, Van Erp TGM, White T, Bockholt HJ, Gollub RL et al. Voxel-based morphometric multisite collaborative study on schizophrenia. Schizophrenia Bulletin. 2009 Jan 1;35(1):82-95. https://doi.org/10.1093/schbul/sbn150