Abstract
Context and objective: Vulvar melanoma is a rare disease. We describe the experience of a single institution and review the literature. design and setting: Retrospective study at the Department of Gynecology, Hospital do Cancer A. C. Camargo. Methods: Eleven patients with vulvar melanoma attended between January 1987 and December 2006 were reviewed regarding clinicopathological characteristics, surgical therapy and follow-up. Results: The initial symptoms were vulvar lesions, pruritus, pain and bleeding. The median age was 64.8 years. The median depth of invasion was 3.08 mm. The staging ranged from IB to IIIC (American Joint Committee on Cancer, 2002). All the patients underwent vulvectomy. Two patients did not undergo primary elective lymphadenectomy. Bilateral inguinal lymphadenectomy was performed on five patients, and one had unilateral inguinal lymphadenectomy. Sentinel lymph node investigation was performed on three patients. Five patients had locoregional recurrence. Prolonged survival was only achieved in the absence of lymph node involvement. The median follow-up was 56 months. The median disease-free survival was 15 months and the median overall survival was 29 months. Conclusions: The prognosis for patients with vulvar melanoma is generally poor, with a high tendency towards regional and distant recurrence. Depth of invasion and lymph node involvement are the most important prognostic factors. In most cases, resection of the lesion with adequate margins may replace vulvectomy. Elective inguinal femoral lymphadenectomy remains the standard lymph node staging procedure. Sentinel lymph node investigation is feasible and should be performed by a multidisciplinary team with experience of this method.
| Original language | Portuguese |
|---|---|
| Pages (from-to) | 38-41 |
| Number of pages | 4 |
| Journal | Sao Paulo Medical Journal |
| Volume | 128 |
| Issue number | 1 |
| State | Published - Jan 1 2010 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Melanoma de vulva : Relato de onze casos e revisão da literatura. / Baiocchi, Glauco; Duprat, João Pedreira; Neves, Rogerio Izar; Fukazawa, Elza Mieko; Landman, Gilles; Guimarães, Gustavo Cardoso; Valadares, Leonardo Jacomo.
In: Sao Paulo Medical Journal, Vol. 128, No. 1, 01.01.2010, p. 38-41.Research output: Contribution to journal › Article
TY - JOUR
T1 - Melanoma de vulva
T2 - Relato de onze casos e revisão da literatura
AU - Baiocchi, Glauco
AU - Duprat, João Pedreira
AU - Neves, Rogerio Izar
AU - Fukazawa, Elza Mieko
AU - Landman, Gilles
AU - Guimarães, Gustavo Cardoso
AU - Valadares, Leonardo Jacomo
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Context and objective: Vulvar melanoma is a rare disease. We describe the experience of a single institution and review the literature. design and setting: Retrospective study at the Department of Gynecology, Hospital do Cancer A. C. Camargo. Methods: Eleven patients with vulvar melanoma attended between January 1987 and December 2006 were reviewed regarding clinicopathological characteristics, surgical therapy and follow-up. Results: The initial symptoms were vulvar lesions, pruritus, pain and bleeding. The median age was 64.8 years. The median depth of invasion was 3.08 mm. The staging ranged from IB to IIIC (American Joint Committee on Cancer, 2002). All the patients underwent vulvectomy. Two patients did not undergo primary elective lymphadenectomy. Bilateral inguinal lymphadenectomy was performed on five patients, and one had unilateral inguinal lymphadenectomy. Sentinel lymph node investigation was performed on three patients. Five patients had locoregional recurrence. Prolonged survival was only achieved in the absence of lymph node involvement. The median follow-up was 56 months. The median disease-free survival was 15 months and the median overall survival was 29 months. Conclusions: The prognosis for patients with vulvar melanoma is generally poor, with a high tendency towards regional and distant recurrence. Depth of invasion and lymph node involvement are the most important prognostic factors. In most cases, resection of the lesion with adequate margins may replace vulvectomy. Elective inguinal femoral lymphadenectomy remains the standard lymph node staging procedure. Sentinel lymph node investigation is feasible and should be performed by a multidisciplinary team with experience of this method.
AB - Context and objective: Vulvar melanoma is a rare disease. We describe the experience of a single institution and review the literature. design and setting: Retrospective study at the Department of Gynecology, Hospital do Cancer A. C. Camargo. Methods: Eleven patients with vulvar melanoma attended between January 1987 and December 2006 were reviewed regarding clinicopathological characteristics, surgical therapy and follow-up. Results: The initial symptoms were vulvar lesions, pruritus, pain and bleeding. The median age was 64.8 years. The median depth of invasion was 3.08 mm. The staging ranged from IB to IIIC (American Joint Committee on Cancer, 2002). All the patients underwent vulvectomy. Two patients did not undergo primary elective lymphadenectomy. Bilateral inguinal lymphadenectomy was performed on five patients, and one had unilateral inguinal lymphadenectomy. Sentinel lymph node investigation was performed on three patients. Five patients had locoregional recurrence. Prolonged survival was only achieved in the absence of lymph node involvement. The median follow-up was 56 months. The median disease-free survival was 15 months and the median overall survival was 29 months. Conclusions: The prognosis for patients with vulvar melanoma is generally poor, with a high tendency towards regional and distant recurrence. Depth of invasion and lymph node involvement are the most important prognostic factors. In most cases, resection of the lesion with adequate margins may replace vulvectomy. Elective inguinal femoral lymphadenectomy remains the standard lymph node staging procedure. Sentinel lymph node investigation is feasible and should be performed by a multidisciplinary team with experience of this method.
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M3 - Article
C2 - 20512279
AN - SCOPUS:77953801359
VL - 128
SP - 38
EP - 41
JO - Sao Paulo Medical Journal
JF - Sao Paulo Medical Journal
SN - 1516-3180
IS - 1
ER -