Melanoma de vulva: Relato de onze casos e revisão da literatura

Translated title of the contribution: Vulvar melanoma: Report on eleven cases and review of the literature

Glauco Baiocchi, João Pedreira Duprat, Rogerio Izar Neves, Elza Mieko Fukazawa, Gilles Landman, Gustavo Cardoso Guimarães, Leonardo Jacomo Valadares

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Context and objective: Vulvar melanoma is a rare disease. We describe the experience of a single institution and review the literature. design and setting: Retrospective study at the Department of Gynecology, Hospital do Cancer A. C. Camargo. Methods: Eleven patients with vulvar melanoma attended between January 1987 and December 2006 were reviewed regarding clinicopathological characteristics, surgical therapy and follow-up. Results: The initial symptoms were vulvar lesions, pruritus, pain and bleeding. The median age was 64.8 years. The median depth of invasion was 3.08 mm. The staging ranged from IB to IIIC (American Joint Committee on Cancer, 2002). All the patients underwent vulvectomy. Two patients did not undergo primary elective lymphadenectomy. Bilateral inguinal lymphadenectomy was performed on five patients, and one had unilateral inguinal lymphadenectomy. Sentinel lymph node investigation was performed on three patients. Five patients had locoregional recurrence. Prolonged survival was only achieved in the absence of lymph node involvement. The median follow-up was 56 months. The median disease-free survival was 15 months and the median overall survival was 29 months. Conclusions: The prognosis for patients with vulvar melanoma is generally poor, with a high tendency towards regional and distant recurrence. Depth of invasion and lymph node involvement are the most important prognostic factors. In most cases, resection of the lesion with adequate margins may replace vulvectomy. Elective inguinal femoral lymphadenectomy remains the standard lymph node staging procedure. Sentinel lymph node investigation is feasible and should be performed by a multidisciplinary team with experience of this method.

Original languagePortuguese
Pages (from-to)38-41
Number of pages4
JournalSao Paulo Medical Journal
Volume128
Issue number1
StatePublished - Jan 1 2010

Fingerprint

Melanoma
Lymph Node Excision
Groin
Lymph Nodes
Cancer Care Facilities
Recurrence
Survival
Hospital Departments
Pruritus
Rare Diseases
Thigh
Gynecology
Disease-Free Survival
Retrospective Studies
Hemorrhage
Pain
Neoplasms

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Baiocchi, G., Duprat, J. P., Neves, R. I., Fukazawa, E. M., Landman, G., Guimarães, G. C., & Valadares, L. J. (2010). Melanoma de vulva: Relato de onze casos e revisão da literatura. Sao Paulo Medical Journal, 128(1), 38-41.
Baiocchi, Glauco ; Duprat, João Pedreira ; Neves, Rogerio Izar ; Fukazawa, Elza Mieko ; Landman, Gilles ; Guimarães, Gustavo Cardoso ; Valadares, Leonardo Jacomo. / Melanoma de vulva : Relato de onze casos e revisão da literatura. In: Sao Paulo Medical Journal. 2010 ; Vol. 128, No. 1. pp. 38-41.
@article{1d5b325ec02f4445b9ff772a398fe422,
title = "Melanoma de vulva: Relato de onze casos e revis{\~a}o da literatura",
abstract = "Context and objective: Vulvar melanoma is a rare disease. We describe the experience of a single institution and review the literature. design and setting: Retrospective study at the Department of Gynecology, Hospital do Cancer A. C. Camargo. Methods: Eleven patients with vulvar melanoma attended between January 1987 and December 2006 were reviewed regarding clinicopathological characteristics, surgical therapy and follow-up. Results: The initial symptoms were vulvar lesions, pruritus, pain and bleeding. The median age was 64.8 years. The median depth of invasion was 3.08 mm. The staging ranged from IB to IIIC (American Joint Committee on Cancer, 2002). All the patients underwent vulvectomy. Two patients did not undergo primary elective lymphadenectomy. Bilateral inguinal lymphadenectomy was performed on five patients, and one had unilateral inguinal lymphadenectomy. Sentinel lymph node investigation was performed on three patients. Five patients had locoregional recurrence. Prolonged survival was only achieved in the absence of lymph node involvement. The median follow-up was 56 months. The median disease-free survival was 15 months and the median overall survival was 29 months. Conclusions: The prognosis for patients with vulvar melanoma is generally poor, with a high tendency towards regional and distant recurrence. Depth of invasion and lymph node involvement are the most important prognostic factors. In most cases, resection of the lesion with adequate margins may replace vulvectomy. Elective inguinal femoral lymphadenectomy remains the standard lymph node staging procedure. Sentinel lymph node investigation is feasible and should be performed by a multidisciplinary team with experience of this method.",
author = "Glauco Baiocchi and Duprat, {Jo{\~a}o Pedreira} and Neves, {Rogerio Izar} and Fukazawa, {Elza Mieko} and Gilles Landman and Guimar{\~a}es, {Gustavo Cardoso} and Valadares, {Leonardo Jacomo}",
year = "2010",
month = "1",
day = "1",
language = "Portuguese",
volume = "128",
pages = "38--41",
journal = "Sao Paulo Medical Journal",
issn = "1516-3180",
publisher = "Associacao Paulista de Medicina",
number = "1",

}

Baiocchi, G, Duprat, JP, Neves, RI, Fukazawa, EM, Landman, G, Guimarães, GC & Valadares, LJ 2010, 'Melanoma de vulva: Relato de onze casos e revisão da literatura', Sao Paulo Medical Journal, vol. 128, no. 1, pp. 38-41.

Melanoma de vulva : Relato de onze casos e revisão da literatura. / Baiocchi, Glauco; Duprat, João Pedreira; Neves, Rogerio Izar; Fukazawa, Elza Mieko; Landman, Gilles; Guimarães, Gustavo Cardoso; Valadares, Leonardo Jacomo.

In: Sao Paulo Medical Journal, Vol. 128, No. 1, 01.01.2010, p. 38-41.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Melanoma de vulva

T2 - Relato de onze casos e revisão da literatura

AU - Baiocchi, Glauco

AU - Duprat, João Pedreira

AU - Neves, Rogerio Izar

AU - Fukazawa, Elza Mieko

AU - Landman, Gilles

AU - Guimarães, Gustavo Cardoso

AU - Valadares, Leonardo Jacomo

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Context and objective: Vulvar melanoma is a rare disease. We describe the experience of a single institution and review the literature. design and setting: Retrospective study at the Department of Gynecology, Hospital do Cancer A. C. Camargo. Methods: Eleven patients with vulvar melanoma attended between January 1987 and December 2006 were reviewed regarding clinicopathological characteristics, surgical therapy and follow-up. Results: The initial symptoms were vulvar lesions, pruritus, pain and bleeding. The median age was 64.8 years. The median depth of invasion was 3.08 mm. The staging ranged from IB to IIIC (American Joint Committee on Cancer, 2002). All the patients underwent vulvectomy. Two patients did not undergo primary elective lymphadenectomy. Bilateral inguinal lymphadenectomy was performed on five patients, and one had unilateral inguinal lymphadenectomy. Sentinel lymph node investigation was performed on three patients. Five patients had locoregional recurrence. Prolonged survival was only achieved in the absence of lymph node involvement. The median follow-up was 56 months. The median disease-free survival was 15 months and the median overall survival was 29 months. Conclusions: The prognosis for patients with vulvar melanoma is generally poor, with a high tendency towards regional and distant recurrence. Depth of invasion and lymph node involvement are the most important prognostic factors. In most cases, resection of the lesion with adequate margins may replace vulvectomy. Elective inguinal femoral lymphadenectomy remains the standard lymph node staging procedure. Sentinel lymph node investigation is feasible and should be performed by a multidisciplinary team with experience of this method.

AB - Context and objective: Vulvar melanoma is a rare disease. We describe the experience of a single institution and review the literature. design and setting: Retrospective study at the Department of Gynecology, Hospital do Cancer A. C. Camargo. Methods: Eleven patients with vulvar melanoma attended between January 1987 and December 2006 were reviewed regarding clinicopathological characteristics, surgical therapy and follow-up. Results: The initial symptoms were vulvar lesions, pruritus, pain and bleeding. The median age was 64.8 years. The median depth of invasion was 3.08 mm. The staging ranged from IB to IIIC (American Joint Committee on Cancer, 2002). All the patients underwent vulvectomy. Two patients did not undergo primary elective lymphadenectomy. Bilateral inguinal lymphadenectomy was performed on five patients, and one had unilateral inguinal lymphadenectomy. Sentinel lymph node investigation was performed on three patients. Five patients had locoregional recurrence. Prolonged survival was only achieved in the absence of lymph node involvement. The median follow-up was 56 months. The median disease-free survival was 15 months and the median overall survival was 29 months. Conclusions: The prognosis for patients with vulvar melanoma is generally poor, with a high tendency towards regional and distant recurrence. Depth of invasion and lymph node involvement are the most important prognostic factors. In most cases, resection of the lesion with adequate margins may replace vulvectomy. Elective inguinal femoral lymphadenectomy remains the standard lymph node staging procedure. Sentinel lymph node investigation is feasible and should be performed by a multidisciplinary team with experience of this method.

UR - http://www.scopus.com/inward/record.url?scp=77953801359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953801359&partnerID=8YFLogxK

M3 - Article

C2 - 20512279

AN - SCOPUS:77953801359

VL - 128

SP - 38

EP - 41

JO - Sao Paulo Medical Journal

JF - Sao Paulo Medical Journal

SN - 1516-3180

IS - 1

ER -

Baiocchi G, Duprat JP, Neves RI, Fukazawa EM, Landman G, Guimarães GC et al. Melanoma de vulva: Relato de onze casos e revisão da literatura. Sao Paulo Medical Journal. 2010 Jan 1;128(1):38-41.