Wall teichoic acid function, biosynthesis, and inhibition

Jonathan G. Swoboda, Jennifer Campbell, Timothy C. Meredith, Suzanne Walker

Research output: Contribution to journalShort surveypeer-review

207 Scopus citations

Abstract

(Figure Presented) Off the wall: Wall teichoic acids (WTAs) are negatively charged glycopolymers found in dense arrays on the surface of Gram-positive bacteria. WTAs have profound effects on the physiology of Gram-positive organisms, and impact everything from cation homeostasis to antibiotic susceptibility to survival in a host. This review summarizes recent advances made toward understanding WTA function, biosynthesis and inhibition.

Original languageEnglish (US)
Pages (from-to)35-45
Number of pages11
JournalChemBioChem
Volume11
Issue number1
DOIs
StatePublished - Jan 4 2010

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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