Wegener granulomatosis simulating bacterial endocarditis

Donald D. Anthony, Ali D. Askari, Terry Wolpaw, Grace McComsey

Research output: Contribution to journalArticle

30 Scopus citations


Cardiac involvement in Wegener granulomatosis is uncommon. We report a case of Wegener granulomatosis that presented as culture-negative endocarditis with aortic valvular vegetation. The clinical manifestations included gingival hyperplasia, gangrenous digital infarcts, mononeuritis multiplex, high fever, inflammatory arthritis, pansinusitis, splenic infarct, and aortic valvular vegetation, which underscore the difficulty of distinguishing systemic vasculitis from bacterial endocarditis. Contrary to the common notion that valvular vegetation is invariably associated with bacterial endocarditis, this case proves that such findings can occur in Wegener granulomatosis as well. Clinicians are guided toward early treatment with corticosteroids and cyclophosphamide to prevent fatal complications.

Original languageEnglish (US)
Pages (from-to)1807-1810
Number of pages4
JournalArchives of Internal Medicine
Issue number15
Publication statusPublished - Aug 9 1999


All Science Journal Classification (ASJC) codes

  • Internal Medicine

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