Wegener granulomatosis simulating bacterial endocarditis

Donald D. Anthony, Ali D. Askari, Terry Wolpaw, Grace McComsey

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Cardiac involvement in Wegener granulomatosis is uncommon. We report a case of Wegener granulomatosis that presented as culture-negative endocarditis with aortic valvular vegetation. The clinical manifestations included gingival hyperplasia, gangrenous digital infarcts, mononeuritis multiplex, high fever, inflammatory arthritis, pansinusitis, splenic infarct, and aortic valvular vegetation, which underscore the difficulty of distinguishing systemic vasculitis from bacterial endocarditis. Contrary to the common notion that valvular vegetation is invariably associated with bacterial endocarditis, this case proves that such findings can occur in Wegener granulomatosis as well. Clinicians are guided toward early treatment with corticosteroids and cyclophosphamide to prevent fatal complications.

Original languageEnglish (US)
Pages (from-to)1807-1810
Number of pages4
JournalArchives of Internal Medicine
Volume159
Issue number15
DOIs
StatePublished - Aug 9 1999

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Bacterial Endocarditis
Granulomatosis with Polyangiitis
Splenic Infarction
Gingival Hyperplasia
Mononeuropathies
Systemic Vasculitis
Endocarditis
Cyclophosphamide
Arthritis
Adrenal Cortex Hormones
Fever

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Anthony, Donald D. ; Askari, Ali D. ; Wolpaw, Terry ; McComsey, Grace. / Wegener granulomatosis simulating bacterial endocarditis. In: Archives of Internal Medicine. 1999 ; Vol. 159, No. 15. pp. 1807-1810.
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Wegener granulomatosis simulating bacterial endocarditis. / Anthony, Donald D.; Askari, Ali D.; Wolpaw, Terry; McComsey, Grace.

In: Archives of Internal Medicine, Vol. 159, No. 15, 09.08.1999, p. 1807-1810.

Research output: Contribution to journalArticle

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