White matter correlates of cognitive capacity studied with diffusion tensor imaging: Implications for cognitive reserve

Marc W. Haut, Maria T. Moran, Melissa A. Lancaster, Hiroto Kuwabara, Michael W. Parsons, Aina Puce

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Cognitive reserve (CR) is a theoretical concept used to explain and study individual differences in cognitive symptom expression in neurological disease. In the absence of neurologic injury or demands on processing, compensatory and protective factors may be considered to represent cognitive capacity (CC), rather than cognitive reserve, per se. We studied the white matter structural correlates of CC in 51 young, healthy participants. White matter structural correlates were obtained from fractional anisotropy (FA) measures using diffusion tensor imaging (DTI). CC was represented by intelligence, reading ability, and years of education, commonly used measures for studying CR. CC was positively correlated with FA in the right posterior inferior longitudinal fasciculus. We observed gender differences in FA (males < females) and tested for gender differences in FA correlates of CC. However, the interaction between gender and CC for areas of FA was not significant. Our data indicate that in the healthy young brain, greater CC correlates with higher FA values in a focal area that does not significantly differ by gender.

Original languageEnglish (US)
Pages (from-to)83-92
Number of pages10
JournalBrain Imaging and Behavior
Volume1
Issue number3-4
DOIs
StatePublished - Nov 1 2007

Fingerprint

Cognitive Reserve
Diffusion Tensor Imaging
Anisotropy
Nervous System Trauma
Neurobehavioral Manifestations
Aptitude
Intelligence
Individuality
White Matter
Reading
Healthy Volunteers
Education
Brain

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Cognitive Neuroscience
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

Cite this

Haut, Marc W. ; Moran, Maria T. ; Lancaster, Melissa A. ; Kuwabara, Hiroto ; Parsons, Michael W. ; Puce, Aina. / White matter correlates of cognitive capacity studied with diffusion tensor imaging : Implications for cognitive reserve. In: Brain Imaging and Behavior. 2007 ; Vol. 1, No. 3-4. pp. 83-92.
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White matter correlates of cognitive capacity studied with diffusion tensor imaging : Implications for cognitive reserve. / Haut, Marc W.; Moran, Maria T.; Lancaster, Melissa A.; Kuwabara, Hiroto; Parsons, Michael W.; Puce, Aina.

In: Brain Imaging and Behavior, Vol. 1, No. 3-4, 01.11.2007, p. 83-92.

Research output: Contribution to journalArticle

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