Whole heart modeling - Spatiotemporal dynamics of electrical wave conduction and propagation

Hui Yang, Yun Chen, Fabio M. Leonelli

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cardiac electrical activities are varying in both space and time. Human heart consists of a fractal network of muscle cells, Purkinje fibers, arteries and veins. Whole-heart modeling of electrical wave conduction and propagation involves a greater level of complexity. Our previous work developed a computer model of the anatomically realistic heart and simulated the electrical conduction with the use of cellular automata. However, simplistic assumptions and rules limit its ability to provide an accurate approximation of real-world dynamics on the complex heart surface, due to sensitive dependence of nonlinear dynamical systems on initial conditions. In this paper, we propose new reaction-diffusion methods and pattern recognition tools to simulate and model spatiotemporal dynamics of electrical wave conduction and propagation on the complex heart surface, which include (i) whole heart model; (ii) 2D isometric graphing of 3D heart geometry; (iii) reaction-diffusion modeling of electrical waves in 2D graph, and (iv) spatiotemporal pattern recognition. Experimental results show that the proposed numerical solution has strong potentials to model the space-time dynamics of electrical wave conduction in the whole heart, thereby achieving a better understanding of disease-altered cardiac mechanisms.

Original languageEnglish (US)
Title of host publication2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages5575-5578
Number of pages4
Volume2016-October
ISBN (Electronic)9781457702204
DOIs
StatePublished - Oct 13 2016
Event38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 - Orlando, United States
Duration: Aug 16 2016Aug 20 2016

Other

Other38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016
CountryUnited States
CityOrlando
Period8/16/168/20/16

Fingerprint

Pattern recognition
Space Simulation
Purkinje Fibers
Nonlinear dynamical systems
Fractals
Cellular automata
Computer Simulation
Muscle Cells
Muscle
Veins
Heart Diseases
Dynamic models
Arteries
Cells
Geometry
Fibers

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this

Yang, H., Chen, Y., & Leonelli, F. M. (2016). Whole heart modeling - Spatiotemporal dynamics of electrical wave conduction and propagation. In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016 (Vol. 2016-October, pp. 5575-5578). [7591990] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/EMBC.2016.7591990
Yang, Hui ; Chen, Yun ; Leonelli, Fabio M. / Whole heart modeling - Spatiotemporal dynamics of electrical wave conduction and propagation. 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Vol. 2016-October Institute of Electrical and Electronics Engineers Inc., 2016. pp. 5575-5578
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Yang, H, Chen, Y & Leonelli, FM 2016, Whole heart modeling - Spatiotemporal dynamics of electrical wave conduction and propagation. in 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. vol. 2016-October, 7591990, Institute of Electrical and Electronics Engineers Inc., pp. 5575-5578, 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016, Orlando, United States, 8/16/16. https://doi.org/10.1109/EMBC.2016.7591990

Whole heart modeling - Spatiotemporal dynamics of electrical wave conduction and propagation. / Yang, Hui; Chen, Yun; Leonelli, Fabio M.

2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Vol. 2016-October Institute of Electrical and Electronics Engineers Inc., 2016. p. 5575-5578 7591990.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Yang H, Chen Y, Leonelli FM. Whole heart modeling - Spatiotemporal dynamics of electrical wave conduction and propagation. In 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2016. Vol. 2016-October. Institute of Electrical and Electronics Engineers Inc. 2016. p. 5575-5578. 7591990 https://doi.org/10.1109/EMBC.2016.7591990