Why inhaling salt water changes what we exhale

Wiwik Watanabe, Matthew Thomas, Robert Clarke, Alexander M. Klibanov, Robert Langer, Jeffrey Katstra, Gerald G. Fuller, Lester C. Griel, Jr., Jennifer Fiegel, David Edwards

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We find that inhaling salt water diminishes subsequently exhaled biomaterial in man and animals due to reversible stabilization of the airway lining fluid (ALF)/air interface as a novel potential means for control of the spread of airborne infectious disease. The mechanism of this phenomenon relates to charge shielding of mucin or mucin-like macromolecules that consequently undergo gelation; this gelation alters the physical properties of the ALF surface and reduces its breakup. Cations in the nebulized solution and apparent surface viscoelasticity of the ALF (more than any other ALF intrinsic physical property) appear to be responsible for the reduced tendency of the ALF to disintegrate into very small droplets. We confirm these effects in vivo and show their reversibility through nebulization of saline solutions to anesthetized bull calves.

Original languageEnglish (US)
Pages (from-to)71-78
Number of pages8
JournalJournal of Colloid And Interface Science
Volume307
Issue number1
DOIs
StatePublished - Mar 1 2007

Fingerprint

Saline water
Linings
Fluids
Mucins
Gelation
Physical properties
Drop breakup
Viscoelasticity
Biocompatible Materials
Macromolecules
Biomaterials
Sodium Chloride
Shielding
Cations
Animals
Stabilization
Positive ions
Air

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry

Cite this

Watanabe, W., Thomas, M., Clarke, R., Klibanov, A. M., Langer, R., Katstra, J., ... Edwards, D. (2007). Why inhaling salt water changes what we exhale. Journal of Colloid And Interface Science, 307(1), 71-78. https://doi.org/10.1016/j.jcis.2006.11.017
Watanabe, Wiwik ; Thomas, Matthew ; Clarke, Robert ; Klibanov, Alexander M. ; Langer, Robert ; Katstra, Jeffrey ; Fuller, Gerald G. ; Griel, Jr., Lester C. ; Fiegel, Jennifer ; Edwards, David. / Why inhaling salt water changes what we exhale. In: Journal of Colloid And Interface Science. 2007 ; Vol. 307, No. 1. pp. 71-78.
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Watanabe, W, Thomas, M, Clarke, R, Klibanov, AM, Langer, R, Katstra, J, Fuller, GG, Griel, Jr., LC, Fiegel, J & Edwards, D 2007, 'Why inhaling salt water changes what we exhale', Journal of Colloid And Interface Science, vol. 307, no. 1, pp. 71-78. https://doi.org/10.1016/j.jcis.2006.11.017

Why inhaling salt water changes what we exhale. / Watanabe, Wiwik; Thomas, Matthew; Clarke, Robert; Klibanov, Alexander M.; Langer, Robert; Katstra, Jeffrey; Fuller, Gerald G.; Griel, Jr., Lester C.; Fiegel, Jennifer; Edwards, David.

In: Journal of Colloid And Interface Science, Vol. 307, No. 1, 01.03.2007, p. 71-78.

Research output: Contribution to journalArticle

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Watanabe W, Thomas M, Clarke R, Klibanov AM, Langer R, Katstra J et al. Why inhaling salt water changes what we exhale. Journal of Colloid And Interface Science. 2007 Mar 1;307(1):71-78. https://doi.org/10.1016/j.jcis.2006.11.017