Wild and cultivated centaurea raphanina subsp. Mixta: A valuable source of bioactive compounds

Spyridon A. Petropoulos, Ângela Fernandes, Maria Ines Dias, Carla Pereira, Ricardo Calhelha, Francesco Di Gioia, Nikolaos Tzortzakis, Marija Ivanov, Marina Sokovic, Lillian Barros, Isabel C.F.R. Ferreira

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Centaurea raphanina subsp. mixta (DC.) Runemark is a wild edible species endemic to Greece. This study evaluated the chemical composition and bioactive properties of wild and cultivated C. raphanina subsp. mixta plants. Wild plants had higher nutritional value than cultivated ones, whereas cultivated plants contained more tocopherols. Glucose and sucrose were higher in cultivated plants and trehalose in wild ones. Oxalic and total organic acids were detected in higher amounts in cultivated samples. The main fatty acids were α-linolenic, linoleic and palmitic acid, while wild plants were richer in polyunsaturated fatty acids. Two pinocembrin derivatives were the main phenolic compounds being detected in higher amounts in wild plants. Regarding the antioxidant activity, wild and cultivated plants were more effective in the oxidative haemolysis (OxHLIA) and thiobarbituric acid reactive substances (TBARS) assays, respectively. Moreover, both extracts showed moderate cytotoxicity in non-tumor cell lines (PLP2), while cultivated plants were more effective against cervical carcinoma (HeLa), breast carcinoma (MCF-7) and non-small lung cancer (NCI-H460) cell lines. Finally, wild plants showed higher antimicrobial activity than cultivated plants against specific pathogens. In conclusion, the cultivation of C. raphanina subsp. mixta showed promising results in terms of tocopherols content and antiproliferative effects, however further research is needed to decrease oxalic acid content.

Original languageEnglish (US)
Article number314
JournalAntioxidants
Volume9
Issue number4
DOIs
StatePublished - Apr 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology

Fingerprint Dive into the research topics of 'Wild and cultivated centaurea raphanina subsp. Mixta: A valuable source of bioactive compounds'. Together they form a unique fingerprint.

  • Cite this

    Petropoulos, S. A., Fernandes, Â., Dias, M. I., Pereira, C., Calhelha, R., Di Gioia, F., Tzortzakis, N., Ivanov, M., Sokovic, M., Barros, L., & Ferreira, I. C. F. R. (2020). Wild and cultivated centaurea raphanina subsp. Mixta: A valuable source of bioactive compounds. Antioxidants, 9(4), [314]. https://doi.org/10.3390/antiox9040314