Wireless, battery-free optoelectronic systems as subdermal implants for local tissue oximetry

Hao Zhang, Philipp Gutruf, Kathleen Meacham, Michael C. Montana, Xingyue Zhao, Antonio M. Chiarelli, Abraham Vázquez-Guardado, Aaron Norris, Luyao Lu, Qinglei Guo, Chenkai Xu, Yixin Wu, Hangbo Zhao, Xin Ning, Wubin Bai, Irawati Kandela, Chad R. Haney, Debashis Chanda, Robert W. Gereau, John A. Rogers

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Monitoring regional tissue oxygenation in animal models and potentially in human subjects can yield insights into the underlying mechanisms of local O 2 -mediated physiological processes and provide diagnostic and therapeutic guidance for relevant disease states. Existing technologies for tissue oxygenation assessments involve some combination of disadvantages in requirements for physical tethers, anesthetics, and special apparatus, often with confounding effects on the natural behaviors of test subjects. This work introduces an entirely wireless and fully implantable platform incorporating (i) microscale optoelectronics for continuous sensing of local hemoglobin dynamics and (ii) advanced designs in continuous, wireless power delivery and data output for tether-free operation. These features support in vivo, highly localized tissue oximetry at sites of interest, including deep brain regions of mice, on untethered, awake animal models. The results create many opportunities for studying various O 2 -mediated processes in naturally behaving subjects, with implications in biomedical research and clinical practice.

Original languageEnglish (US)
Article numbereaaw0873
JournalScience Advances
Volume5
Issue number3
DOIs
StatePublished - Jan 1 2019

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oximetry
electric batteries
animal models
oxygenation
anesthetics
hemoglobin
microbalances
brain
mice
delivery
platforms
requirements
output

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)
  • General

Cite this

Zhang, H., Gutruf, P., Meacham, K., Montana, M. C., Zhao, X., Chiarelli, A. M., ... Rogers, J. A. (2019). Wireless, battery-free optoelectronic systems as subdermal implants for local tissue oximetry. Science Advances, 5(3), [eaaw0873]. https://doi.org/10.1126/sciadv.aaw0873
Zhang, Hao ; Gutruf, Philipp ; Meacham, Kathleen ; Montana, Michael C. ; Zhao, Xingyue ; Chiarelli, Antonio M. ; Vázquez-Guardado, Abraham ; Norris, Aaron ; Lu, Luyao ; Guo, Qinglei ; Xu, Chenkai ; Wu, Yixin ; Zhao, Hangbo ; Ning, Xin ; Bai, Wubin ; Kandela, Irawati ; Haney, Chad R. ; Chanda, Debashis ; Gereau, Robert W. ; Rogers, John A. / Wireless, battery-free optoelectronic systems as subdermal implants for local tissue oximetry. In: Science Advances. 2019 ; Vol. 5, No. 3.
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abstract = "Monitoring regional tissue oxygenation in animal models and potentially in human subjects can yield insights into the underlying mechanisms of local O 2 -mediated physiological processes and provide diagnostic and therapeutic guidance for relevant disease states. Existing technologies for tissue oxygenation assessments involve some combination of disadvantages in requirements for physical tethers, anesthetics, and special apparatus, often with confounding effects on the natural behaviors of test subjects. This work introduces an entirely wireless and fully implantable platform incorporating (i) microscale optoelectronics for continuous sensing of local hemoglobin dynamics and (ii) advanced designs in continuous, wireless power delivery and data output for tether-free operation. These features support in vivo, highly localized tissue oximetry at sites of interest, including deep brain regions of mice, on untethered, awake animal models. The results create many opportunities for studying various O 2 -mediated processes in naturally behaving subjects, with implications in biomedical research and clinical practice.",
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Zhang, H, Gutruf, P, Meacham, K, Montana, MC, Zhao, X, Chiarelli, AM, Vázquez-Guardado, A, Norris, A, Lu, L, Guo, Q, Xu, C, Wu, Y, Zhao, H, Ning, X, Bai, W, Kandela, I, Haney, CR, Chanda, D, Gereau, RW & Rogers, JA 2019, 'Wireless, battery-free optoelectronic systems as subdermal implants for local tissue oximetry', Science Advances, vol. 5, no. 3, eaaw0873. https://doi.org/10.1126/sciadv.aaw0873

Wireless, battery-free optoelectronic systems as subdermal implants for local tissue oximetry. / Zhang, Hao; Gutruf, Philipp; Meacham, Kathleen; Montana, Michael C.; Zhao, Xingyue; Chiarelli, Antonio M.; Vázquez-Guardado, Abraham; Norris, Aaron; Lu, Luyao; Guo, Qinglei; Xu, Chenkai; Wu, Yixin; Zhao, Hangbo; Ning, Xin; Bai, Wubin; Kandela, Irawati; Haney, Chad R.; Chanda, Debashis; Gereau, Robert W.; Rogers, John A.

In: Science Advances, Vol. 5, No. 3, eaaw0873, 01.01.2019.

Research output: Contribution to journalArticle

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T1 - Wireless, battery-free optoelectronic systems as subdermal implants for local tissue oximetry

AU - Zhang, Hao

AU - Gutruf, Philipp

AU - Meacham, Kathleen

AU - Montana, Michael C.

AU - Zhao, Xingyue

AU - Chiarelli, Antonio M.

AU - Vázquez-Guardado, Abraham

AU - Norris, Aaron

AU - Lu, Luyao

AU - Guo, Qinglei

AU - Xu, Chenkai

AU - Wu, Yixin

AU - Zhao, Hangbo

AU - Ning, Xin

AU - Bai, Wubin

AU - Kandela, Irawati

AU - Haney, Chad R.

AU - Chanda, Debashis

AU - Gereau, Robert W.

AU - Rogers, John A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Monitoring regional tissue oxygenation in animal models and potentially in human subjects can yield insights into the underlying mechanisms of local O 2 -mediated physiological processes and provide diagnostic and therapeutic guidance for relevant disease states. Existing technologies for tissue oxygenation assessments involve some combination of disadvantages in requirements for physical tethers, anesthetics, and special apparatus, often with confounding effects on the natural behaviors of test subjects. This work introduces an entirely wireless and fully implantable platform incorporating (i) microscale optoelectronics for continuous sensing of local hemoglobin dynamics and (ii) advanced designs in continuous, wireless power delivery and data output for tether-free operation. These features support in vivo, highly localized tissue oximetry at sites of interest, including deep brain regions of mice, on untethered, awake animal models. The results create many opportunities for studying various O 2 -mediated processes in naturally behaving subjects, with implications in biomedical research and clinical practice.

AB - Monitoring regional tissue oxygenation in animal models and potentially in human subjects can yield insights into the underlying mechanisms of local O 2 -mediated physiological processes and provide diagnostic and therapeutic guidance for relevant disease states. Existing technologies for tissue oxygenation assessments involve some combination of disadvantages in requirements for physical tethers, anesthetics, and special apparatus, often with confounding effects on the natural behaviors of test subjects. This work introduces an entirely wireless and fully implantable platform incorporating (i) microscale optoelectronics for continuous sensing of local hemoglobin dynamics and (ii) advanced designs in continuous, wireless power delivery and data output for tether-free operation. These features support in vivo, highly localized tissue oximetry at sites of interest, including deep brain regions of mice, on untethered, awake animal models. The results create many opportunities for studying various O 2 -mediated processes in naturally behaving subjects, with implications in biomedical research and clinical practice.

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JO - Indian Journal of Pure and Applied Physics

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Zhang H, Gutruf P, Meacham K, Montana MC, Zhao X, Chiarelli AM et al. Wireless, battery-free optoelectronic systems as subdermal implants for local tissue oximetry. Science Advances. 2019 Jan 1;5(3). eaaw0873. https://doi.org/10.1126/sciadv.aaw0873