Withdrawal from chronic nicotine administration impairs contextual fear conditioning in C57BL/6 mice

Jennifer A. Davis, John R. James, Steven J. Siegel, Thomas J. Gould

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

The effects of acute nicotine administration (0.09 mg/kg nicotine), chronic nicotine administration (6.3 mg/kg/d nicotine for 14 d), and withdrawal from chronic nicotine administration on fear conditioning in C57BL/6 mice were examined. Mice were trained using two coterminating conditioned stimulus (30 s; 85 dB white noise)-unconditioned stimulus (2 s; 0.57 mA foot shock) pairings and tested 24 h later for contextual and cued fear conditioning. Acute nicotine administration enhanced contextual fear conditioning, chronic nicotine administration had no effect on contextual fear conditioning, and withdrawal from chronic nicotine administration impaired contextual fear conditioning. Plasma nicotine concentrations were similar after acute and chronic treatment and were within the range reported for smokers. During withdrawal, concentrations of nicotine were undetectable. An acute dose of nicotine (0.09 mg/kg) during withdrawal from chronic nicotine treatment reversed withdrawal-associated deficits in contextual fear conditioning. The results suggest that tolerance to the effects of nicotine on contextual fear conditioning develops with chronic nicotine treatment at a physiologically relevant dose, and withdrawal from this chronic nicotine treatment is associated with impairments in contextual fear conditioning. These findings provide a model of how the effects of nicotine on learning may contribute to the development and maintenance of nicotine addiction.

Original languageEnglish (US)
Pages (from-to)8708-8713
Number of pages6
JournalJournal of Neuroscience
Volume25
Issue number38
DOIs
StatePublished - Sep 21 2005

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Nicotine
Inbred C57BL Mouse
Fear
Conditioning (Psychology)
Foot
Shock

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Davis, Jennifer A. ; James, John R. ; Siegel, Steven J. ; Gould, Thomas J. / Withdrawal from chronic nicotine administration impairs contextual fear conditioning in C57BL/6 mice. In: Journal of Neuroscience. 2005 ; Vol. 25, No. 38. pp. 8708-8713.
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abstract = "The effects of acute nicotine administration (0.09 mg/kg nicotine), chronic nicotine administration (6.3 mg/kg/d nicotine for 14 d), and withdrawal from chronic nicotine administration on fear conditioning in C57BL/6 mice were examined. Mice were trained using two coterminating conditioned stimulus (30 s; 85 dB white noise)-unconditioned stimulus (2 s; 0.57 mA foot shock) pairings and tested 24 h later for contextual and cued fear conditioning. Acute nicotine administration enhanced contextual fear conditioning, chronic nicotine administration had no effect on contextual fear conditioning, and withdrawal from chronic nicotine administration impaired contextual fear conditioning. Plasma nicotine concentrations were similar after acute and chronic treatment and were within the range reported for smokers. During withdrawal, concentrations of nicotine were undetectable. An acute dose of nicotine (0.09 mg/kg) during withdrawal from chronic nicotine treatment reversed withdrawal-associated deficits in contextual fear conditioning. The results suggest that tolerance to the effects of nicotine on contextual fear conditioning develops with chronic nicotine treatment at a physiologically relevant dose, and withdrawal from this chronic nicotine treatment is associated with impairments in contextual fear conditioning. These findings provide a model of how the effects of nicotine on learning may contribute to the development and maintenance of nicotine addiction.",
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Withdrawal from chronic nicotine administration impairs contextual fear conditioning in C57BL/6 mice. / Davis, Jennifer A.; James, John R.; Siegel, Steven J.; Gould, Thomas J.

In: Journal of Neuroscience, Vol. 25, No. 38, 21.09.2005, p. 8708-8713.

Research output: Contribution to journalArticle

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