Wnt/β-catenin signaling induces the expression and activity of βTrCP ubiquitin ligase receptor

Vladimir Spiegelman, Thomas J. Slaga, Michele Pagano, Toshinari Minamoto, Ze'ev Ronai, Serge Y. Fuchs

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

β-Transducing repeat-containing protein (βTrCP) targets the ubiquitination and subsequent degradation of both β-catenin and IκB, thereby playing an important role in β-catenin/Tcf and NF-κB-dependent signaling. Here evidence is presented that β-catenin/Tcf signaling elevates the expression of βTrCP mRNA and protein in a Tcf-dependent manner, which does not require βTrCP transcription. Induction of βTrCP expression by the β-catenin/Tcf pathway results in an accelerated degradation of the wild-type β-catenin, suggesting that the negative feedback loop regulation may control the β-catenin/Tcf pathway. This signaling also upregulated NF-κB transactivation without affecting the activity of IκB kinase, thereby establishing that the maintenance of the βTrCP level is important for coordination between β-catenin/Tcf and NF-κB signaling.

Original languageEnglish (US)
Pages (from-to)877-882
Number of pages6
JournalMolecular cell
Volume5
Issue number5
DOIs
StatePublished - Jan 1 2000

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Catenins
Ubiquitin-Protein Ligases
Proteins
Ubiquitination
Transcriptional Activation
Phosphotransferases
Maintenance
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

Spiegelman, Vladimir ; Slaga, Thomas J. ; Pagano, Michele ; Minamoto, Toshinari ; Ronai, Ze'ev ; Fuchs, Serge Y. / Wnt/β-catenin signaling induces the expression and activity of βTrCP ubiquitin ligase receptor. In: Molecular cell. 2000 ; Vol. 5, No. 5. pp. 877-882.
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Wnt/β-catenin signaling induces the expression and activity of βTrCP ubiquitin ligase receptor. / Spiegelman, Vladimir; Slaga, Thomas J.; Pagano, Michele; Minamoto, Toshinari; Ronai, Ze'ev; Fuchs, Serge Y.

In: Molecular cell, Vol. 5, No. 5, 01.01.2000, p. 877-882.

Research output: Contribution to journalArticle

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