Women with low iron stores absorb iron from soybeans

Laura E. Murray-Kolb, Ross Welch, Elizabeth C. Theil, John L. Beard

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

Background: Worldwide, 30% of the population, a greater proportion of whom are women and children, is iron deficient. Soybeans are a major source of nonheme iron in many human diets, but information on iron bioavailability is still conflicting. Because much of soybean iron is in ferritin [distinct from the poorly bioavailable iron in cereals resulting from interactions between calcium, Fe(III), phytate, and proteins in the meal], soybeans provide a target for manipulating seed iron composition to achieve increased iron bioavailability. Objective: The aim was to reevaluate soybean iron bioavailability. Design: Eighteen women, most with marginal iron deficiency, consumed meals with intrinsically labeled (55Fe) soybeans (hydroponically grown and nonnodulating) as soup (n = 11) or muffins (n = 7) and a reference dose of 59Fe as ferrous sulfate in ascorbate solution. The radioactivity in red cells was measured 14 and 28 d later. Results: The mean 55Fe absorption from either soup or muffins was 27% and that from the reference dose was 61%. 55Fe was distributed approximately equally between protein (49.3 ± 3.0%) and phytate, a contrast with nodulating soybeans likely caused by a high phosphate content in the growth medium. There was an expected inverse correlation (r = -0.793, P < 0.001) between red cell radioactivity and serum ferritin concentration. Conclusions: These results show that soybeans appear to be a good source of nutritional iron in marginally iron-deficient individuals. More study is needed on the effect of plant nodulation on the form of soybean iron, aimed at enhancing bioavailability to combat iron deficiency in at-risk populations.

Original languageEnglish (US)
Pages (from-to)180-184
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume77
Issue number1
DOIs
StatePublished - Jan 1 2003

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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