In a Digital Signal Processing (DSP) course for senior Electrical Engineering majors, students received two different types of instructional delivery messages (online text only and text along with a simulation tool: MATLAB) via two different types of instructional delivery media (Desktop PC and Personal Digital Assistant (PDA)). An experimental study was designed to investigate the potential main effects and the interaction of these two independent variables: instructional delivery message and instructional delivery media on three dependent variables: students' learning achievement, their intention, and satisfaction to use those instructional strategies. This study was a 2 × 2 randomized post-test design. A Multivariate Analysis of Variance (MANOVA) was used to analyze the collected data. Significant results were found in independent variables. However, there was no significant interaction found between the two studied independent variables for all the three dependent measures.