The goal for a patient-centered care model is to involve patient/family members into the healthcare delivery, to meet the expectation and preferences of patients, and to share the care decision-making process with patients. A patient-centered care model could improve patients' clinical and intermediate health outcomes and increase the satisfaction of the healthcare "services". An ideal patient-centered care plan should be established from a professional standardized clinical workflow. A clear standardized care plan not only avoids the logistical operations in a healthcare facility affected by patient's personal preferences or immature treatment expectations, but it also ensures that the quality of care could be delivered by the providers in respectful manners. A human computer interaction (HCI) approach with a case study is applied and discussed to develop a workflow-oriented perspective patient-centered care model. In order to achieve win-win situations for patients, family members, and care providers in a patient-centered care model, communication between patients and care providers and communication among care providers will facilitate a relevant workflow-oriented patient-centered care model.