Working environment and myeloproliferative neoplasm: A population-based case-control study following a cluster investigation

Karyn Heavner, Carol Ann Gross-Davis, Arthur L. Frank, Craig Newschaffer, Judith Klotz, Igor Burstyn

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Occupational exposures, including those to polycyclic aromatic hydrocarbons (PAH), are suspected risk factors for myeloproliferative neoplasms (MPN). Methods: We investigated occupational exposures and MPN risk (54 cases and 472 controls) in a population-based case-control study in three rural Pennsylvania counties. Occupational histories, coded to SIC/SOC 1980, were linked to a previously created PAH job-exposure matrix. Odds ratios for industry (17 categories), occupation (26 categories), and PAH exposure were adjusted using logistic regression. Results: No industries or occupations were strongly or consistently associated with increased MPN risk. Analysis of employment duration found that being employed for 5 or more years in transportation, communications, and other public utilities was associated with MPN risk. There was no indication of an association with cumulative PAH exposure. Conclusions: These few associations did not appear to have a common exposure. This exploratory study does not support the hypothesis that occupational exposure, including PAH, are strong risk factors for MPNs.

Original languageEnglish (US)
Pages (from-to)595-604
Number of pages10
JournalAmerican Journal of Industrial Medicine
Volume58
Issue number6
DOIs
StatePublished - Jun 1 2015

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Polycyclic Aromatic Hydrocarbons
Case-Control Studies
Occupational Exposure
Population
Neoplasms
Occupations
Industry
Logistic Models
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Heavner, Karyn ; Gross-Davis, Carol Ann ; Frank, Arthur L. ; Newschaffer, Craig ; Klotz, Judith ; Burstyn, Igor. / Working environment and myeloproliferative neoplasm : A population-based case-control study following a cluster investigation. In: American Journal of Industrial Medicine. 2015 ; Vol. 58, No. 6. pp. 595-604.
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Working environment and myeloproliferative neoplasm : A population-based case-control study following a cluster investigation. / Heavner, Karyn; Gross-Davis, Carol Ann; Frank, Arthur L.; Newschaffer, Craig; Klotz, Judith; Burstyn, Igor.

In: American Journal of Industrial Medicine, Vol. 58, No. 6, 01.06.2015, p. 595-604.

Research output: Contribution to journalArticle

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