Working to Increase Stability through Exercise (WISE): Study protocol for a pragmatic randomized controlled trial of a coached exercise program to reduce serious fall-related injuries

Christopher Sciamanna, Noel Ballentine, Melissa Jean Bopp, Jennifer S. Brach, Vernon Chinchilli, Joseph T. Ciccolo, Molly B. Conroy, Abigail Fisher, Edward Fox, Susan L. Greenspan, M. Jan De Beur, Suzanne, Kalen Kearcher, Jennifer Kraschnewski, Kathleen M. McTigue, Edward McAuley, Natalia E. Morone, Anuradha Paranjape, Sol Rodriguez-Colon, Andrew Rosenzweig, Joshua Morrison SmythKerry J. Stewart, Heather Stuckey

Research output: Contribution to journalArticle

Abstract

Approximately one-third of older adults fall each year and fall-related injuries are a leading cause of death and disability among this rapidly expanding age group. Despite the availability of bisphosphonates to reduce fractures, concerns over side effects have dramatically reduced use, suggesting that other treatment options are needed. Though many smaller studies have shown that physical activity programs can reduce falls, no study has been adequately powered to detect a reduction in fall-related injuries. We present the design of a three-year randomized controlled clinical trial of 1130 adults age 65 and older with a past history of fragility fractures (e.g., vertebral, fall-related). The main aim is to determine the impact of a community-based multicomponent (strength, balance, aerobic) physical activity program led by trained volunteers (or delivered via DVD) and accompanied by coaching and oversight, by telephone and in-person, by a fitness professional. The main outcome measure is serious fall-related injuries. Secondary outcomes include health care utilization, bone and muscle mass, loneliness, health-related quality of life and mood. The study represents the first large clinical trial of a comprehensive physical activity program to reduce secondary injuries among patients with a history of fragility fracture.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalContemporary Clinical Trials
Volume74
DOIs
StatePublished - Nov 1 2018

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Randomized Controlled Trials
Exercise
Wounds and Injuries
Patient Acceptance of Health Care
Loneliness
Diphosphonates
Telephone
Cause of Death
Volunteers
Age Groups
Quality of Life
Outcome Assessment (Health Care)
Clinical Trials
Bone and Bones
Muscles
Mentoring
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

Sciamanna, Christopher ; Ballentine, Noel ; Bopp, Melissa Jean ; Brach, Jennifer S. ; Chinchilli, Vernon ; Ciccolo, Joseph T. ; Conroy, Molly B. ; Fisher, Abigail ; Fox, Edward ; Greenspan, Susan L. ; Jan De Beur, Suzanne, M. ; Kearcher, Kalen ; Kraschnewski, Jennifer ; McTigue, Kathleen M. ; McAuley, Edward ; Morone, Natalia E. ; Paranjape, Anuradha ; Rodriguez-Colon, Sol ; Rosenzweig, Andrew ; Smyth, Joshua Morrison ; Stewart, Kerry J. ; Stuckey, Heather. / Working to Increase Stability through Exercise (WISE) : Study protocol for a pragmatic randomized controlled trial of a coached exercise program to reduce serious fall-related injuries. In: Contemporary Clinical Trials. 2018 ; Vol. 74. pp. 1-10.
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abstract = "Approximately one-third of older adults fall each year and fall-related injuries are a leading cause of death and disability among this rapidly expanding age group. Despite the availability of bisphosphonates to reduce fractures, concerns over side effects have dramatically reduced use, suggesting that other treatment options are needed. Though many smaller studies have shown that physical activity programs can reduce falls, no study has been adequately powered to detect a reduction in fall-related injuries. We present the design of a three-year randomized controlled clinical trial of 1130 adults age 65 and older with a past history of fragility fractures (e.g., vertebral, fall-related). The main aim is to determine the impact of a community-based multicomponent (strength, balance, aerobic) physical activity program led by trained volunteers (or delivered via DVD) and accompanied by coaching and oversight, by telephone and in-person, by a fitness professional. The main outcome measure is serious fall-related injuries. Secondary outcomes include health care utilization, bone and muscle mass, loneliness, health-related quality of life and mood. The study represents the first large clinical trial of a comprehensive physical activity program to reduce secondary injuries among patients with a history of fragility fracture.",
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Working to Increase Stability through Exercise (WISE) : Study protocol for a pragmatic randomized controlled trial of a coached exercise program to reduce serious fall-related injuries. / Sciamanna, Christopher; Ballentine, Noel; Bopp, Melissa Jean; Brach, Jennifer S.; Chinchilli, Vernon; Ciccolo, Joseph T.; Conroy, Molly B.; Fisher, Abigail; Fox, Edward; Greenspan, Susan L.; Jan De Beur, Suzanne, M.; Kearcher, Kalen; Kraschnewski, Jennifer; McTigue, Kathleen M.; McAuley, Edward; Morone, Natalia E.; Paranjape, Anuradha; Rodriguez-Colon, Sol; Rosenzweig, Andrew; Smyth, Joshua Morrison; Stewart, Kerry J.; Stuckey, Heather.

In: Contemporary Clinical Trials, Vol. 74, 01.11.2018, p. 1-10.

Research output: Contribution to journalArticle

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AU - Ballentine, Noel

AU - Bopp, Melissa Jean

AU - Brach, Jennifer S.

AU - Chinchilli, Vernon

AU - Ciccolo, Joseph T.

AU - Conroy, Molly B.

AU - Fisher, Abigail

AU - Fox, Edward

AU - Greenspan, Susan L.

AU - Jan De Beur, Suzanne, M.

AU - Kearcher, Kalen

AU - Kraschnewski, Jennifer

AU - McTigue, Kathleen M.

AU - McAuley, Edward

AU - Morone, Natalia E.

AU - Paranjape, Anuradha

AU - Rodriguez-Colon, Sol

AU - Rosenzweig, Andrew

AU - Smyth, Joshua Morrison

AU - Stewart, Kerry J.

AU - Stuckey, Heather

PY - 2018/11/1

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N2 - Approximately one-third of older adults fall each year and fall-related injuries are a leading cause of death and disability among this rapidly expanding age group. Despite the availability of bisphosphonates to reduce fractures, concerns over side effects have dramatically reduced use, suggesting that other treatment options are needed. Though many smaller studies have shown that physical activity programs can reduce falls, no study has been adequately powered to detect a reduction in fall-related injuries. We present the design of a three-year randomized controlled clinical trial of 1130 adults age 65 and older with a past history of fragility fractures (e.g., vertebral, fall-related). The main aim is to determine the impact of a community-based multicomponent (strength, balance, aerobic) physical activity program led by trained volunteers (or delivered via DVD) and accompanied by coaching and oversight, by telephone and in-person, by a fitness professional. The main outcome measure is serious fall-related injuries. Secondary outcomes include health care utilization, bone and muscle mass, loneliness, health-related quality of life and mood. The study represents the first large clinical trial of a comprehensive physical activity program to reduce secondary injuries among patients with a history of fragility fracture.

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