X-ray Crystal Structures of Escherichia coli RNA Polymerase with Switch Region Binding Inhibitors Enable Rational Design of Squaramides with an Improved Fraction Unbound to Human Plasma Protein

Vadim Molodtsov, Paul R. Fleming, Charles J. Eyermann, Andrew D. Ferguson, Melinda A. Foulk, David C. McKinney, Craig E. Masse, Ed T. Buurman, Katsuhiko S. Murakami

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