Yeast TAF(II)145 required for transcription of G1/S cyclin genes and regulated by the cellular growth state

Scott S. Walker, Wu Cheng Shen, Joseph C. Reese, Lynne M. Apone, Michael R. Green

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

TFIID comprises the TATA box-binding protein and a set of highly conserved associated factors (TAF(II)S). yTAF(II)145, the core subunit of the yeast TAF(II) complex, is dispensable for transcription of most yeast genes but specifically required for progression through G1/S. Here we show that transcription of G1 and certain B-type cyclin genes is dependent upon yTAF(II)145. At high cell density or following nutrient deprivation, yeast cells cease division, enter a G0-like state, and terminate transcription of most genes. In this stationary phase, we find that the levels of yTAF(II)145, several other yTAF(II)S, and TBP are drastically reduced. Collectively, our results indicate that yTAF(II)145 and other TF(II)D components have a specialized role in transcriptional regulation of cell cycle progression and growth control.

Original languageEnglish (US)
Pages (from-to)607-614
Number of pages8
JournalCell
Volume90
Issue number4
DOIs
StatePublished - Aug 22 1997

Fingerprint

Cyclin G1
Cyclins
Transcription
Yeast
Genes
Yeasts
Growth
Cells
Transcription Factor TFIID
TATA-Box Binding Protein
Cyclin B
Cell Division
Nutrients
Cell Cycle
Cell Count
Food

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Walker, Scott S. ; Shen, Wu Cheng ; Reese, Joseph C. ; Apone, Lynne M. ; Green, Michael R. / Yeast TAF(II)145 required for transcription of G1/S cyclin genes and regulated by the cellular growth state. In: Cell. 1997 ; Vol. 90, No. 4. pp. 607-614.
@article{b11a5cc8fefa4ae3b32bf5e3f2e7e209,
title = "Yeast TAF(II)145 required for transcription of G1/S cyclin genes and regulated by the cellular growth state",
abstract = "TFIID comprises the TATA box-binding protein and a set of highly conserved associated factors (TAF(II)S). yTAF(II)145, the core subunit of the yeast TAF(II) complex, is dispensable for transcription of most yeast genes but specifically required for progression through G1/S. Here we show that transcription of G1 and certain B-type cyclin genes is dependent upon yTAF(II)145. At high cell density or following nutrient deprivation, yeast cells cease division, enter a G0-like state, and terminate transcription of most genes. In this stationary phase, we find that the levels of yTAF(II)145, several other yTAF(II)S, and TBP are drastically reduced. Collectively, our results indicate that yTAF(II)145 and other TF(II)D components have a specialized role in transcriptional regulation of cell cycle progression and growth control.",
author = "Walker, {Scott S.} and Shen, {Wu Cheng} and Reese, {Joseph C.} and Apone, {Lynne M.} and Green, {Michael R.}",
year = "1997",
month = "8",
day = "22",
doi = "10.1016/S0092-8674(00)80522-X",
language = "English (US)",
volume = "90",
pages = "607--614",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "4",

}

Yeast TAF(II)145 required for transcription of G1/S cyclin genes and regulated by the cellular growth state. / Walker, Scott S.; Shen, Wu Cheng; Reese, Joseph C.; Apone, Lynne M.; Green, Michael R.

In: Cell, Vol. 90, No. 4, 22.08.1997, p. 607-614.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Yeast TAF(II)145 required for transcription of G1/S cyclin genes and regulated by the cellular growth state

AU - Walker, Scott S.

AU - Shen, Wu Cheng

AU - Reese, Joseph C.

AU - Apone, Lynne M.

AU - Green, Michael R.

PY - 1997/8/22

Y1 - 1997/8/22

N2 - TFIID comprises the TATA box-binding protein and a set of highly conserved associated factors (TAF(II)S). yTAF(II)145, the core subunit of the yeast TAF(II) complex, is dispensable for transcription of most yeast genes but specifically required for progression through G1/S. Here we show that transcription of G1 and certain B-type cyclin genes is dependent upon yTAF(II)145. At high cell density or following nutrient deprivation, yeast cells cease division, enter a G0-like state, and terminate transcription of most genes. In this stationary phase, we find that the levels of yTAF(II)145, several other yTAF(II)S, and TBP are drastically reduced. Collectively, our results indicate that yTAF(II)145 and other TF(II)D components have a specialized role in transcriptional regulation of cell cycle progression and growth control.

AB - TFIID comprises the TATA box-binding protein and a set of highly conserved associated factors (TAF(II)S). yTAF(II)145, the core subunit of the yeast TAF(II) complex, is dispensable for transcription of most yeast genes but specifically required for progression through G1/S. Here we show that transcription of G1 and certain B-type cyclin genes is dependent upon yTAF(II)145. At high cell density or following nutrient deprivation, yeast cells cease division, enter a G0-like state, and terminate transcription of most genes. In this stationary phase, we find that the levels of yTAF(II)145, several other yTAF(II)S, and TBP are drastically reduced. Collectively, our results indicate that yTAF(II)145 and other TF(II)D components have a specialized role in transcriptional regulation of cell cycle progression and growth control.

UR - http://www.scopus.com/inward/record.url?scp=0030786957&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030786957&partnerID=8YFLogxK

U2 - 10.1016/S0092-8674(00)80522-X

DO - 10.1016/S0092-8674(00)80522-X

M3 - Article

C2 - 9288741

AN - SCOPUS:0030786957

VL - 90

SP - 607

EP - 614

JO - Cell

JF - Cell

SN - 0092-8674

IS - 4

ER -