Yeast TAF(II)145 required for transcription of G1/S cyclin genes and regulated by the cellular growth state

Scott S. Walker, Wu Cheng Shen, Joseph C. Reese, Lynne M. Apone, Michael R. Green

Research output: Contribution to journalArticle

126 Scopus citations

Abstract

TFIID comprises the TATA box-binding protein and a set of highly conserved associated factors (TAF(II)S). yTAF(II)145, the core subunit of the yeast TAF(II) complex, is dispensable for transcription of most yeast genes but specifically required for progression through G1/S. Here we show that transcription of G1 and certain B-type cyclin genes is dependent upon yTAF(II)145. At high cell density or following nutrient deprivation, yeast cells cease division, enter a G0-like state, and terminate transcription of most genes. In this stationary phase, we find that the levels of yTAF(II)145, several other yTAF(II)S, and TBP are drastically reduced. Collectively, our results indicate that yTAF(II)145 and other TF(II)D components have a specialized role in transcriptional regulation of cell cycle progression and growth control.

Original languageEnglish (US)
Pages (from-to)607-614
Number of pages8
JournalCell
Volume90
Issue number4
DOIs
StatePublished - Aug 22 1997

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Yeast TAF(II)145 required for transcription of G1/S cyclin genes and regulated by the cellular growth state'. Together they form a unique fingerprint.

  • Cite this