Young coconut juice, a potential therapeutic agent that could significantly reduce some pathologies associated with Alzheimer's disease: Novel findings

Nisaudah Radenahmad, Farid Saleh, Kitja Sawangjaroen, Uraporn Vongvatcharanon, Patchara Subhadhirasakul, Wilart Rundorn, Boonsirm Withyachumnarnkul, James R. Connor

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Brains from ovariectomised (ovx) rats can display features similar to those observed in menopausal women with Alzheimer's disease (AD), and oestrogen seems to play a key role. Preliminary studies on young coconut juice (YCJ) have reported the presence of oestrogen-like components in it. The aim of the study was to investigate the effects of YCJ on the AD pathological changes in the brains of ovx rats. Rat groups included sham-operated, ovx, ovx+oestradiol benzoate (EB) and ovx+YCJ. Brain sections (4m) were taken and were immunostained with -amyloid (A) 1-42, glial fibrillary acidic protein (GFAP) (an intermediate neurofilament of astrocytes) and Tau-1 antibodies. A 1-42, GFAP and Tau-1 are considered as reliable biomarkers of amyloidosis, astrogliosis and tauopathy (neurofibrillary tangles), respectively, which in turn are characteristic features associated with AD. The serum oestradiol (E2) level was measured using a chemiluminescent immunoassay technique. YCJ restored the serum E2 to levels significantly (P<·001) higher than that of the ovx group, and even that of the sham group. A deposition was significantly (P<·0001) reduced in the cerebral cortex of the YCJ group, as compared with the ovx group and with the sham and ovx+EB groups (P<·01). A similar trend was observed in relation to GFAP expression in the cerebral cortex and to Tau-1 expression in the hippocampus. This is a novel study demonstrating that YCJ could have positive future implications in the prevention and treatment of AD in menopausal women.

Original languageEnglish (US)
Pages (from-to)738-746
Number of pages9
JournalBritish Journal of Nutrition
Volume105
Issue number5
DOIs
StatePublished - Mar 14 2011

Fingerprint

Cocos
Alzheimer Disease
Pathology
Glial Fibrillary Acidic Protein
Cerebral Cortex
Brain
Estrogens
Therapeutics
Tauopathies
Neurofibrillary Tangles
Intermediate Filaments
Amyloidosis
Serum
Immunoassay
Amyloid
Astrocytes
Estradiol
Hippocampus
Biomarkers
Antibodies

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Radenahmad, Nisaudah ; Saleh, Farid ; Sawangjaroen, Kitja ; Vongvatcharanon, Uraporn ; Subhadhirasakul, Patchara ; Rundorn, Wilart ; Withyachumnarnkul, Boonsirm ; Connor, James R. / Young coconut juice, a potential therapeutic agent that could significantly reduce some pathologies associated with Alzheimer's disease : Novel findings. In: British Journal of Nutrition. 2011 ; Vol. 105, No. 5. pp. 738-746.
@article{899020c2600a491c9ee1d9848f465fc5,
title = "Young coconut juice, a potential therapeutic agent that could significantly reduce some pathologies associated with Alzheimer's disease: Novel findings",
abstract = "Brains from ovariectomised (ovx) rats can display features similar to those observed in menopausal women with Alzheimer's disease (AD), and oestrogen seems to play a key role. Preliminary studies on young coconut juice (YCJ) have reported the presence of oestrogen-like components in it. The aim of the study was to investigate the effects of YCJ on the AD pathological changes in the brains of ovx rats. Rat groups included sham-operated, ovx, ovx+oestradiol benzoate (EB) and ovx+YCJ. Brain sections (4m) were taken and were immunostained with -amyloid (A) 1-42, glial fibrillary acidic protein (GFAP) (an intermediate neurofilament of astrocytes) and Tau-1 antibodies. A 1-42, GFAP and Tau-1 are considered as reliable biomarkers of amyloidosis, astrogliosis and tauopathy (neurofibrillary tangles), respectively, which in turn are characteristic features associated with AD. The serum oestradiol (E2) level was measured using a chemiluminescent immunoassay technique. YCJ restored the serum E2 to levels significantly (P<·001) higher than that of the ovx group, and even that of the sham group. A deposition was significantly (P<·0001) reduced in the cerebral cortex of the YCJ group, as compared with the ovx group and with the sham and ovx+EB groups (P<·01). A similar trend was observed in relation to GFAP expression in the cerebral cortex and to Tau-1 expression in the hippocampus. This is a novel study demonstrating that YCJ could have positive future implications in the prevention and treatment of AD in menopausal women.",
author = "Nisaudah Radenahmad and Farid Saleh and Kitja Sawangjaroen and Uraporn Vongvatcharanon and Patchara Subhadhirasakul and Wilart Rundorn and Boonsirm Withyachumnarnkul and Connor, {James R.}",
year = "2011",
month = "3",
day = "14",
doi = "10.1017/S0007114510004241",
language = "English (US)",
volume = "105",
pages = "738--746",
journal = "British Journal of Nutrition",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "5",

}

Radenahmad, N, Saleh, F, Sawangjaroen, K, Vongvatcharanon, U, Subhadhirasakul, P, Rundorn, W, Withyachumnarnkul, B & Connor, JR 2011, 'Young coconut juice, a potential therapeutic agent that could significantly reduce some pathologies associated with Alzheimer's disease: Novel findings', British Journal of Nutrition, vol. 105, no. 5, pp. 738-746. https://doi.org/10.1017/S0007114510004241

Young coconut juice, a potential therapeutic agent that could significantly reduce some pathologies associated with Alzheimer's disease : Novel findings. / Radenahmad, Nisaudah; Saleh, Farid; Sawangjaroen, Kitja; Vongvatcharanon, Uraporn; Subhadhirasakul, Patchara; Rundorn, Wilart; Withyachumnarnkul, Boonsirm; Connor, James R.

In: British Journal of Nutrition, Vol. 105, No. 5, 14.03.2011, p. 738-746.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Young coconut juice, a potential therapeutic agent that could significantly reduce some pathologies associated with Alzheimer's disease

T2 - Novel findings

AU - Radenahmad, Nisaudah

AU - Saleh, Farid

AU - Sawangjaroen, Kitja

AU - Vongvatcharanon, Uraporn

AU - Subhadhirasakul, Patchara

AU - Rundorn, Wilart

AU - Withyachumnarnkul, Boonsirm

AU - Connor, James R.

PY - 2011/3/14

Y1 - 2011/3/14

N2 - Brains from ovariectomised (ovx) rats can display features similar to those observed in menopausal women with Alzheimer's disease (AD), and oestrogen seems to play a key role. Preliminary studies on young coconut juice (YCJ) have reported the presence of oestrogen-like components in it. The aim of the study was to investigate the effects of YCJ on the AD pathological changes in the brains of ovx rats. Rat groups included sham-operated, ovx, ovx+oestradiol benzoate (EB) and ovx+YCJ. Brain sections (4m) were taken and were immunostained with -amyloid (A) 1-42, glial fibrillary acidic protein (GFAP) (an intermediate neurofilament of astrocytes) and Tau-1 antibodies. A 1-42, GFAP and Tau-1 are considered as reliable biomarkers of amyloidosis, astrogliosis and tauopathy (neurofibrillary tangles), respectively, which in turn are characteristic features associated with AD. The serum oestradiol (E2) level was measured using a chemiluminescent immunoassay technique. YCJ restored the serum E2 to levels significantly (P<·001) higher than that of the ovx group, and even that of the sham group. A deposition was significantly (P<·0001) reduced in the cerebral cortex of the YCJ group, as compared with the ovx group and with the sham and ovx+EB groups (P<·01). A similar trend was observed in relation to GFAP expression in the cerebral cortex and to Tau-1 expression in the hippocampus. This is a novel study demonstrating that YCJ could have positive future implications in the prevention and treatment of AD in menopausal women.

AB - Brains from ovariectomised (ovx) rats can display features similar to those observed in menopausal women with Alzheimer's disease (AD), and oestrogen seems to play a key role. Preliminary studies on young coconut juice (YCJ) have reported the presence of oestrogen-like components in it. The aim of the study was to investigate the effects of YCJ on the AD pathological changes in the brains of ovx rats. Rat groups included sham-operated, ovx, ovx+oestradiol benzoate (EB) and ovx+YCJ. Brain sections (4m) were taken and were immunostained with -amyloid (A) 1-42, glial fibrillary acidic protein (GFAP) (an intermediate neurofilament of astrocytes) and Tau-1 antibodies. A 1-42, GFAP and Tau-1 are considered as reliable biomarkers of amyloidosis, astrogliosis and tauopathy (neurofibrillary tangles), respectively, which in turn are characteristic features associated with AD. The serum oestradiol (E2) level was measured using a chemiluminescent immunoassay technique. YCJ restored the serum E2 to levels significantly (P<·001) higher than that of the ovx group, and even that of the sham group. A deposition was significantly (P<·0001) reduced in the cerebral cortex of the YCJ group, as compared with the ovx group and with the sham and ovx+EB groups (P<·01). A similar trend was observed in relation to GFAP expression in the cerebral cortex and to Tau-1 expression in the hippocampus. This is a novel study demonstrating that YCJ could have positive future implications in the prevention and treatment of AD in menopausal women.

UR - http://www.scopus.com/inward/record.url?scp=79953137074&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953137074&partnerID=8YFLogxK

U2 - 10.1017/S0007114510004241

DO - 10.1017/S0007114510004241

M3 - Article

C2 - 21114897

AN - SCOPUS:79953137074

VL - 105

SP - 738

EP - 746

JO - British Journal of Nutrition

JF - British Journal of Nutrition

SN - 0007-1145

IS - 5

ER -