ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression

Xianjiang Lan, Ren Ren, Ruopeng Feng, Lana C. Ly, Yemin Lan, Zhe Zhang, Nicholas Aboreden, Kunhua Qin, John R. Horton, Jeremy D. Grevet, Thiyagaraj Mayuranathan, Osheiza Abdulmalik, Cheryl A. Keller, Belinda Giardine, Ross C. Hardison, Merlin Crossley, Mitchell J. Weiss, Xiaodong Cheng, Junwei Shi, Gerd A. Blobel

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Lan et al. show that the transcription factor ZNF410 has a single direct target gene, the NuRD component CHD4, through which it silences the fetal-type β-globin genes in adult erythroid cells. The exquisite specificity of ZNF410 could be exploited therapeutically for treatment of hemoglobinopathies.

Original languageEnglish (US)
Pages (from-to)239-254.e8
JournalMolecular cell
Volume81
Issue number2
DOIs
StatePublished - Jan 21 2021

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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