ZnS nanocrystal cytotoxicity is influenced by capping agent chemical structure and duration of time in suspension

Justin N. Weilnau, Sarah E. Black, Veronica J. Chehata, Michael P. Schmidt, Kimberly L. Holt, Lindsay M. Carl, Collin J. Straka, Anderson L. Marsh, Walter A. Patton, Courtney M. Lappas

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

As a result of their characteristic physical and optical properties, including their size, intense fluorescence, broad excitation, narrow emission and resistance to photobleaching, semiconductor nanocrystals are potentially useful for a variety of biological applications including molecular imaging, live-cell labeling, photodynamic therapy and targeted drug delivery. In this study, zinc sulfide (ZnS) semiconductor nanocrystals were synthesized in the 3 to 4 nm size range with selected capping agents intended to protect the nanocrystal core and increase its biological compatibility. We show that the biocompatibility of ZnS nanocrystals with primary murine splenocytes is influenced by the chemical structure of the outer capping agent on the nanocrystal. Additionally, the cytotoxicity of ZnS nanocrystals increases markedly as a function of time spent in suspension in phosphate-buffered saline (PBS). These data suggest that the potential therapeutic and/or biological use of ZnS nanocrystals is inherently dependent upon the proper choice of capping agent, as well as the conditions of nanocrystal preparation and storage.

Original languageEnglish (US)
Pages (from-to)227-237
Number of pages11
JournalJournal of Applied Toxicology
Volume33
Issue number3
DOIs
StatePublished - Mar 2013

All Science Journal Classification (ASJC) codes

  • Toxicology

Fingerprint Dive into the research topics of 'ZnS nanocrystal cytotoxicity is influenced by capping agent chemical structure and duration of time in suspension'. Together they form a unique fingerprint.

Cite this