Zoster incidence in human immunodeficiency virus-infected hemophiliacs and homosexual men, 1984-1997

Eric A. Engels, Philip S. Rosenberg, Robert J. Biggar, Mitchell Gail, James J. Goedert, Thomas R. O'Brien, Charles Rabkin, Barbara L. Kroner, Susan L. Wilson, Louis M. Aledort, Stephanie Seremetes, M. Elaine Eyster, Donna Di Michele, Maragaret W. Hilgartner, B. Barbara Konkle, P. Phillip Blatt, Gilbert C. White, Alan R. Cohen, Anne L. Angiolillo, Naomi Luban & 11 others Craig M. Kessler, Michael M. Lederman, Cindy Leissinger, Marilyn Manco-Johnson, W. Keith Hoots, Philippe De Moerloose, Angelos Hatzakis, A. Anastasia Karafoulidou, Titika Mandalaki, Wolfgang Schramm, Sabine Eichinger

    Research output: Contribution to journalArticle

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    Abstract

    Zoster is an important clinical problem for human immunodeficiency virus type 1 (HIV)-infected patients. Risk factors for zoster and trends in incidence in HIV-infected hemophiliacs and homosexual men (n = 1218) were examined. From 1984 to 1997, 174 zoster cases were identified (average yearly incidence, 2.5%). Prior zoster episodes were associated with increased risk for a subsequent episode (relative risk [RR], 4.30; 95% confidence interval [CI], 3.11-5.95). Among hemophiliacs, children and adolescents had the highest zoster risk, and zoster risk declined with age (RR, 0.80 per decade; 95% CI, 0.68-0.93). These findings suggest that HIV-infected persons do not produce or maintain adequate booster responses after varicella zoster virus exposure. Zoster risk was relatively constant when CD4 cell counts >200 cells/mm3 but increased steeply below this level. During the 14 years of follow-up, zoster incidence declined 9% per year. This trend occurred despite decreasing CD4 cell counts and was unexplained by zidovudine or acyclovir use.

    Original languageEnglish (US)
    Pages (from-to)1784-1789
    Number of pages6
    JournalJournal of Infectious Diseases
    Volume180
    Issue number6
    DOIs
    StatePublished - Dec 17 1999

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    Herpes Zoster
    HIV
    Incidence
    HIV-1
    CD4 Lymphocyte Count
    Confidence Intervals
    Human Herpesvirus 3
    Acyclovir
    Sexual Minorities
    Zidovudine

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Infectious Diseases

    Cite this

    Engels, E. A., Rosenberg, P. S., Biggar, R. J., Gail, M., Goedert, J. J., O'Brien, T. R., ... Eichinger, S. (1999). Zoster incidence in human immunodeficiency virus-infected hemophiliacs and homosexual men, 1984-1997. Journal of Infectious Diseases, 180(6), 1784-1789. https://doi.org/10.1086/315146
    Engels, Eric A. ; Rosenberg, Philip S. ; Biggar, Robert J. ; Gail, Mitchell ; Goedert, James J. ; O'Brien, Thomas R. ; Rabkin, Charles ; Kroner, Barbara L. ; Wilson, Susan L. ; Aledort, Louis M. ; Seremetes, Stephanie ; Eyster, M. Elaine ; Di Michele, Donna ; Hilgartner, Maragaret W. ; Konkle, B. Barbara ; Blatt, P. Phillip ; White, Gilbert C. ; Cohen, Alan R. ; Angiolillo, Anne L. ; Luban, Naomi ; Kessler, Craig M. ; Lederman, Michael M. ; Leissinger, Cindy ; Manco-Johnson, Marilyn ; Hoots, W. Keith ; De Moerloose, Philippe ; Hatzakis, Angelos ; Karafoulidou, A. Anastasia ; Mandalaki, Titika ; Schramm, Wolfgang ; Eichinger, Sabine. / Zoster incidence in human immunodeficiency virus-infected hemophiliacs and homosexual men, 1984-1997. In: Journal of Infectious Diseases. 1999 ; Vol. 180, No. 6. pp. 1784-1789.
    @article{1fa677d969b24aa79ca04ec490197e58,
    title = "Zoster incidence in human immunodeficiency virus-infected hemophiliacs and homosexual men, 1984-1997",
    abstract = "Zoster is an important clinical problem for human immunodeficiency virus type 1 (HIV)-infected patients. Risk factors for zoster and trends in incidence in HIV-infected hemophiliacs and homosexual men (n = 1218) were examined. From 1984 to 1997, 174 zoster cases were identified (average yearly incidence, 2.5{\%}). Prior zoster episodes were associated with increased risk for a subsequent episode (relative risk [RR], 4.30; 95{\%} confidence interval [CI], 3.11-5.95). Among hemophiliacs, children and adolescents had the highest zoster risk, and zoster risk declined with age (RR, 0.80 per decade; 95{\%} CI, 0.68-0.93). These findings suggest that HIV-infected persons do not produce or maintain adequate booster responses after varicella zoster virus exposure. Zoster risk was relatively constant when CD4 cell counts >200 cells/mm3 but increased steeply below this level. During the 14 years of follow-up, zoster incidence declined 9{\%} per year. This trend occurred despite decreasing CD4 cell counts and was unexplained by zidovudine or acyclovir use.",
    author = "Engels, {Eric A.} and Rosenberg, {Philip S.} and Biggar, {Robert J.} and Mitchell Gail and Goedert, {James J.} and O'Brien, {Thomas R.} and Charles Rabkin and Kroner, {Barbara L.} and Wilson, {Susan L.} and Aledort, {Louis M.} and Stephanie Seremetes and Eyster, {M. Elaine} and {Di Michele}, Donna and Hilgartner, {Maragaret W.} and Konkle, {B. Barbara} and Blatt, {P. Phillip} and White, {Gilbert C.} and Cohen, {Alan R.} and Angiolillo, {Anne L.} and Naomi Luban and Kessler, {Craig M.} and Lederman, {Michael M.} and Cindy Leissinger and Marilyn Manco-Johnson and Hoots, {W. Keith} and {De Moerloose}, Philippe and Angelos Hatzakis and Karafoulidou, {A. Anastasia} and Titika Mandalaki and Wolfgang Schramm and Sabine Eichinger",
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    Engels, EA, Rosenberg, PS, Biggar, RJ, Gail, M, Goedert, JJ, O'Brien, TR, Rabkin, C, Kroner, BL, Wilson, SL, Aledort, LM, Seremetes, S, Eyster, ME, Di Michele, D, Hilgartner, MW, Konkle, BB, Blatt, PP, White, GC, Cohen, AR, Angiolillo, AL, Luban, N, Kessler, CM, Lederman, MM, Leissinger, C, Manco-Johnson, M, Hoots, WK, De Moerloose, P, Hatzakis, A, Karafoulidou, AA, Mandalaki, T, Schramm, W & Eichinger, S 1999, 'Zoster incidence in human immunodeficiency virus-infected hemophiliacs and homosexual men, 1984-1997', Journal of Infectious Diseases, vol. 180, no. 6, pp. 1784-1789. https://doi.org/10.1086/315146

    Zoster incidence in human immunodeficiency virus-infected hemophiliacs and homosexual men, 1984-1997. / Engels, Eric A.; Rosenberg, Philip S.; Biggar, Robert J.; Gail, Mitchell; Goedert, James J.; O'Brien, Thomas R.; Rabkin, Charles; Kroner, Barbara L.; Wilson, Susan L.; Aledort, Louis M.; Seremetes, Stephanie; Eyster, M. Elaine; Di Michele, Donna; Hilgartner, Maragaret W.; Konkle, B. Barbara; Blatt, P. Phillip; White, Gilbert C.; Cohen, Alan R.; Angiolillo, Anne L.; Luban, Naomi; Kessler, Craig M.; Lederman, Michael M.; Leissinger, Cindy; Manco-Johnson, Marilyn; Hoots, W. Keith; De Moerloose, Philippe; Hatzakis, Angelos; Karafoulidou, A. Anastasia; Mandalaki, Titika; Schramm, Wolfgang; Eichinger, Sabine.

    In: Journal of Infectious Diseases, Vol. 180, No. 6, 17.12.1999, p. 1784-1789.

    Research output: Contribution to journalArticle

    TY - JOUR

    T1 - Zoster incidence in human immunodeficiency virus-infected hemophiliacs and homosexual men, 1984-1997

    AU - Engels, Eric A.

    AU - Rosenberg, Philip S.

    AU - Biggar, Robert J.

    AU - Gail, Mitchell

    AU - Goedert, James J.

    AU - O'Brien, Thomas R.

    AU - Rabkin, Charles

    AU - Kroner, Barbara L.

    AU - Wilson, Susan L.

    AU - Aledort, Louis M.

    AU - Seremetes, Stephanie

    AU - Eyster, M. Elaine

    AU - Di Michele, Donna

    AU - Hilgartner, Maragaret W.

    AU - Konkle, B. Barbara

    AU - Blatt, P. Phillip

    AU - White, Gilbert C.

    AU - Cohen, Alan R.

    AU - Angiolillo, Anne L.

    AU - Luban, Naomi

    AU - Kessler, Craig M.

    AU - Lederman, Michael M.

    AU - Leissinger, Cindy

    AU - Manco-Johnson, Marilyn

    AU - Hoots, W. Keith

    AU - De Moerloose, Philippe

    AU - Hatzakis, Angelos

    AU - Karafoulidou, A. Anastasia

    AU - Mandalaki, Titika

    AU - Schramm, Wolfgang

    AU - Eichinger, Sabine

    PY - 1999/12/17

    Y1 - 1999/12/17

    N2 - Zoster is an important clinical problem for human immunodeficiency virus type 1 (HIV)-infected patients. Risk factors for zoster and trends in incidence in HIV-infected hemophiliacs and homosexual men (n = 1218) were examined. From 1984 to 1997, 174 zoster cases were identified (average yearly incidence, 2.5%). Prior zoster episodes were associated with increased risk for a subsequent episode (relative risk [RR], 4.30; 95% confidence interval [CI], 3.11-5.95). Among hemophiliacs, children and adolescents had the highest zoster risk, and zoster risk declined with age (RR, 0.80 per decade; 95% CI, 0.68-0.93). These findings suggest that HIV-infected persons do not produce or maintain adequate booster responses after varicella zoster virus exposure. Zoster risk was relatively constant when CD4 cell counts >200 cells/mm3 but increased steeply below this level. During the 14 years of follow-up, zoster incidence declined 9% per year. This trend occurred despite decreasing CD4 cell counts and was unexplained by zidovudine or acyclovir use.

    AB - Zoster is an important clinical problem for human immunodeficiency virus type 1 (HIV)-infected patients. Risk factors for zoster and trends in incidence in HIV-infected hemophiliacs and homosexual men (n = 1218) were examined. From 1984 to 1997, 174 zoster cases were identified (average yearly incidence, 2.5%). Prior zoster episodes were associated with increased risk for a subsequent episode (relative risk [RR], 4.30; 95% confidence interval [CI], 3.11-5.95). Among hemophiliacs, children and adolescents had the highest zoster risk, and zoster risk declined with age (RR, 0.80 per decade; 95% CI, 0.68-0.93). These findings suggest that HIV-infected persons do not produce or maintain adequate booster responses after varicella zoster virus exposure. Zoster risk was relatively constant when CD4 cell counts >200 cells/mm3 but increased steeply below this level. During the 14 years of follow-up, zoster incidence declined 9% per year. This trend occurred despite decreasing CD4 cell counts and was unexplained by zidovudine or acyclovir use.

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    DO - 10.1086/315146

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    Engels EA, Rosenberg PS, Biggar RJ, Gail M, Goedert JJ, O'Brien TR et al. Zoster incidence in human immunodeficiency virus-infected hemophiliacs and homosexual men, 1984-1997. Journal of Infectious Diseases. 1999 Dec 17;180(6):1784-1789. https://doi.org/10.1086/315146